ZFIN ID: ZDB-GENE-110408-4
Gene Name: solute carrier family 6 member 2
Gene Symbol: slc6a2    Nomenclature History

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Previous Name: si:dkey-182h7.3

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have dopamine:sodium symporter activity and norepinephrine:sodium symporter activity. Predicted to be involved in dopamine uptake involved in synaptic transmission and norepinephrine transport. Predicted to localize to the neuron projection; neuronal cell body membrane; and presynaptic membrane. Human ortholog(s) of this gene implicated in hypertension and neurocirculatory asthenia. Orthologous to human SLC6A2 (solute carrier family 6 member 2).
Genome Resources: Alliance (1),  Gene:565776 (1),  Ensembl(GRCz11):ENSDARG00000016141 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
cf5Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
cf6Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
cf7Tg Transgenic Insertion Unknown Unknown DNA_AND_CRISPR
sa13869 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa21005 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-slc6a2 1
    CRISPR2-slc6a2 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH slc6a2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    postural orthostatic tachycardia syndrome Alliance ?Orthostatic intolerance 604715
    DISEASE ASSOCIATED WITH slc6a2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process dopamine uptake involved in synaptic transmission (more)
    Cellular Component integral component of membrane (more)
    Molecular Function neurotransmitter:sodium symporter activity (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000175 Sodium:neurotransmitter symporter
    Homologous_superfamily IPR037272 Sodium:neurotransmitter symporter superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA slc6a2-201 (1)    Ensembl 5388
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slc6a2 No data available
    MARKER RELATIONSHIPS
    slc6a2 Contained in: [BAC] DKEY-182H7 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_689046 (1) 2605 nt
    Genomic GenBank:BX663609 (1) 248960 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1R3H6 (1) 625 aa
    Sequence Information (all 7)
    ORTHOLOGY for slc6a2 ( Chr: 7 )
    CITATIONS (24)