ZFIN ID: ZDB-GENE-110408-27
Gene Name: relaxin family peptide receptor 2b
Gene Symbol: rxfp2b    Nomenclature History

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Previous Names: rxfp2a, si:dkey-1o1.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have G protein-coupled peptide receptor activity. Predicted to be involved in activation of adenylate cyclase activity; adenylate cyclase-activating G protein-coupled receptor signaling pathway; and hormone-mediated signaling pathway. Predicted to localize to the integral component of plasma membrane. Human ortholog(s) of this gene implicated in cryptorchidism. Is expressed in female organism; male organism; and ovary. Orthologous to human RXFP2 (relaxin family peptide receptor 2).
Genome Resources: Alliance (1),  Gene:566888 (1),  Ensembl(GRCz11):ENSDARG00000019660 (1)
Note: In March of 2012 this gene was found to be orthologous (both AA and synteny) to human and mouse RXFP2. The curator named this gene rxfp2a, in accordance with Zebrafish Nomenclature Guidelines. In the same month, Yegorov and Good (2012) named this gene rxpfb. Subsequently, two additional publications have maintained Yegorov and Good's nomenclature. In November of 2015 the names and gene symbols of both paralogs were changed to reflect a request filed with NCBI that was forwarded to the ZFIN nomenclature coordinator.
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa22678 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa28490 Point Mutation Unknown Unknown ENU
    sa28491 Point Mutation Unknown Unknown ENU
    sa35927 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa42578 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH rxfp2b HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH rxfp2b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process G protein-coupled receptor signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function G protein-coupled receptor activity (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000276 G protein-coupled receptor, rhodopsin-like
    Repeat IPR001611 Leucine-rich repeat
    Repeat IPR002172 Low-density lipoprotein (LDL) receptor class A repeat
    Repeat IPR003591 Leucine-rich repeat, typical subtype
    Family IPR008112 Relaxin receptor
    Domain IPR017452 GPCR, rhodopsin-like, 7TM
    Conserved_site IPR023415 Low-density lipoprotein (LDL) receptor class A, conserved site
    Homologous_superfamily IPR032675 Leucine-rich repeat domain superfamily
    Homologous_superfamily IPR036055 LDL receptor-like superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    aberrant processed transcript rxfp2b-204 (1)    Ensembl 2523
    mRNA rxfp2b-203 (1)    Ensembl 2510
    ncRNA rxfp2b-003 (1)    Ensembl 516
    rxfp2b-004 (1)    Ensembl 436
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rxfp2b No data available
    MARKER RELATIONSHIPS
    rxfp2b Contained in: [BAC] DKEY-1O1 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001328082 (1)
    Genomic GenBank:CR536612 (1) 224998 bp Blast at MegaBLAST
    Polypeptide UniProtKB:E6Y2S4 (1) 750 aa
    Sequence Information (all 13)
    ORTHOLOGY for rxfp2b ( Chr: 15 )
    CITATIONS (19)