ZFIN ID: ZDB-GENE-110408-15
Gene Name: potassium voltage-gated channel, shaker-related subfamily, member 1a
Gene Symbol: kcna1a    Nomenclature History

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Previous Names: kcna1, Kv1.1 (1), G62942 (1), Kv1.1b (1), si:ch73-333m22.1 (1), wu:fa27a01

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have delayed rectifier potassium channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to localize to several cellular components, including main axon; neuronal cell body; and voltage-gated potassium channel complex. Is expressed in several structures, including gill; heart; hindbrain; opercular flap; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in episodic ataxia type 1. Orthologous to human KCNA1 (potassium voltage-gated channel subfamily A member 1).
Genome Resources: Alliance (1),  Gene:795942 (1),  Ensembl(GRCz11):ENSDARG00000062942 (1)
GENE EXPRESSION
All Expression Data: 6 figures from 3 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
p181 Point Mutation Exon 1 Missense ENU
p410 Indel Unknown Unknown CRISPR
sa38062 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-kcna1a
    1
    CRISPR2-kcna1a 1
    MO1-kcna1a N/A 1
    MO2-kcna1a N/A 1
    PHENOTYPE
    Data: Fig. 1 from Wolman et al., 2015
    Observed in:
    DISEASE ASSOCIATED WITH kcna1a HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    episodic ataxia type 1 Alliance Episodic ataxia/myokymia syndrome 160120
    DISEASE ASSOCIATED WITH kcna1a VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process ion transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ion channel activity (more)
    GO Terms (all 19)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kcna1a-202 (1)    Ensembl 3380
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kcna1a No data available
    MARKER RELATIONSHIPS
    kcna1a Contained in: [BAC] CH73-333M22 (1)
    kcna1a Encodes: [EST] fa27a01
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005163044 (1) 5788 nt
    Genomic GenBank:FO904916 (1) 56353 nt
    Select Tool
    Polypeptide UniProtKB:E7FFE9 (1) 492 aa
    Sequence Information (all 8)
    ORTHOLOGY for kcna1a ( Chr: 25 )
    CITATIONS (23)