ZFIN ID: ZDB-GENE-110408-13
Gene Name: gamma-glutamyltransferase 1b
Gene Symbol: ggt1b    Nomenclature History

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Previous Name: si:dkey-47k14.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have glutathione hydrolase activity and peptidyltransferase activity. Predicted to be involved in several processes, including peptide metabolic process; response to estradiol; and response to lipopolysaccharide. Predicted to localize to the plasma membrane. Human ortholog(s) of this gene implicated in gamma-glutamyl transpeptidase deficiency. Orthologous to several human genes including GGT1 (gamma-glutamyltransferase 1).
Genome Resources: Alliance (1),  Gene:569014 (1),  Ensembl(GRCz11):ENSDARG00000018342 (2)
GENE EXPRESSION
All Expression Data: Fig. 8 from Sant et al., 2017
Wild-type Stages, Structures: Larval:Day 4 (96.0h-120.0h) to Larval:Day 4 (96.0h-120.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la011888Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la017577Tg Transgenic Insertion Unknown Unknown DNA
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH ggt1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    gamma-glutamyl transpeptidase deficiency Alliance ?Glutathioninuria 231950
    DISEASE ASSOCIATED WITH ggt1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process glutathione catabolic process (more)
    Cellular Component plasma membrane (more)
    Molecular Function glutathione hydrolase activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000101 Gamma-glutamyltranspeptidase
    Homologous_superfamily IPR029055 Nucleophile aminohydrolases, N-terminal
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA ggt1b-201 (1)    Ensembl 2468
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM ggt1b No data available
    MARKER RELATIONSHIPS
    ggt1b Contained in: [BAC] DKEY-47K14 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_692376 (1)
    Genomic GenBank:BX005006 (1) 232594 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F8W5P0 (1) 574 aa
    Sequence Information (all 5)
    ORTHOLOGY for ggt1b ( Chr: 10 )
    CITATIONS (21)