ZFIN ID: ZDB-GENE-110407-11
Gene Name: chloride channel, voltage-sensitive 5b
Gene Symbol: clcn5b    Nomenclature History

{{control.fieldName}} Edit

ID: {{control.nomenID}}
{{control.fieldName}}:
Reason:
Comments:

Attributions

{{pub.zdbID}}
Previous Names: clcn5, si:dkey-171c9.2

Add new Alias

Alias
Attribution

Attributions for Alias: {{control.newAlias}}

{{pub.zdbID}}

Delete Alias:

(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have chloride ion binding activity; solute:proton antiporter activity; and voltage-gated chloride channel activity. Predicted to be involved in chloride transport and transmembrane transport. Predicted to localize to Golgi apparatus; cytoplasmic vesicle; and integral component of plasma membrane. Is expressed in several structures, including eye; gill; heart; liver; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in Dent disease; X-linked nephrolithiasis type I; X-linked recessive hypophosphatemic rickets; and low molecular weight proteinuria with hypercalciuric nephrocalcinosis. Orthologous to human CLCN5 (chloride voltage-gated channel 5).
Genome Resources: Alliance (1),  Gene:557584 (1),  Ensembl(GRCz11):ENSDARG00000022466 (2)
GENE EXPRESSION
All Expression Data: Fig. 2 from Wang et al., 2015
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa20918 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH clcn5b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Dent disease Alliance Dent disease 300009
    low molecular weight proteinuria with hypercalciuric nephrocalcinosis Alliance Proteinuria, low molecular weight, with hypercalciuric nephrocalcinosis 308990
    X-linked nephrolithiasis type I Alliance Nephrolithiasis, type I 310468
    X-linked recessive hypophosphatemic rickets Alliance Hypophosphatemic rickets 300554
    DISEASE ASSOCIATED WITH clcn5b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process chloride transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function voltage-gated chloride channel activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA clcn5b-201 (1)    Ensembl 6823
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM clcn5b No data available
    MARKER RELATIONSHIPS
    clcn5b Contained in: [BAC] CH211-15B10 (1), DKEY-171C9 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_680670 (1) 2976 nt
    Genomic GenBank:CR381635 (1) 173058 nt
    Select Tool
    Polypeptide UniProtKB:E7FFG9 (1) 811 aa
    Sequence Information (all 8)
    ORTHOLOGY for clcn5b ( Chr: 7 )
    CITATIONS (17)