ZFIN ID: ZDB-GENE-110331-1
Gene Name: mannosidase, alpha, class 2A, member 2
Gene Symbol: man2a2    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 25 Mapping Details/Browsers
Description: Predicted to have alpha-mannosidase activity. Predicted to be involved in N-glycan processing; mannose metabolic process; and protein deglycosylation. Predicted to localize to Golgi membrane. Used to study schizophrenia. Orthologous to human MAN2A2 (mannosidase alpha class 2A member 2).
Genome Resources: Alliance (1),  Gene:100333987 (1),  Ensembl(GRCz11):ENSDARG00000063101 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a298 Complex Unknown Unknown CRISPR
sa3293 Point Mutation Unknown Premature Stop ENU
sa7259 Point Mutation Unknown Splice Site ENU
sa13130 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24615 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa39473 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa44244 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-man2a2 1
    CRISPR2-man2a2 1
    CRISPR3-man2a2 1
    CRISPR4-man2a2 1
    DISEASE ASSOCIATED WITH man2a2 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH man2a2 VIA EXPERIMENTAL MODELS
    Human Disease Fish Conditions Citations
    schizophrenia man2a2a298/a298 standard conditions Thyme et al., 2019
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process carbohydrate metabolic process (more)
    Cellular Component integral component of membrane (more)
    Molecular Function alpha-mannosidase activity (more)
    GO Terms (all 14)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA man2a2-201 (1)    Ensembl 7815
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM man2a2 No data available
    MARKER RELATIONSHIPS
    man2a2 Contained in: [BAC] CH211-107J19 (1), CH211-256J21 (1)
    [Fosmid] CH1073-517O12 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_009297800 (1)
    Genomic GenBank:CR407564 (1) 180337 nt
    Select Tool
    Polypeptide UniProtKB:E7EYL2 (1) 1151 aa
    Sequence Information (all 17)
    ORTHOLOGY for man2a2 ( Chr: 25 )
    CITATIONS (16)