Gene

man2a2

ID
ZDB-GENE-110331-1
Name
mannosidase, alpha, class 2A, member 2
Symbol
man2a2 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 25 Mapping Details/Browsers
Description
Predicted to enable alpha-mannosidase activity. Predicted to be involved in N-glycan processing and protein deglycosylation. Predicted to act upstream of or within mannose metabolic process. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi membrane. Used to study schizophrenia. Orthologous to human MAN2A2 (mannosidase alpha class 2A member 2).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Thyme et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With man2a2 Human Ortholog
No data available
Associated With man2a2 Via Experimental Models
Human Disease Fish Conditions Citations
schizophrenia man2a2a298/a298 standard conditions Thyme et al., 2019
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000602 Glycoside hydrolase family 38, N-terminal domain
Domain IPR011682 Glycosyl hydrolase family 38, C-terminal
Domain IPR015341 Glycoside hydrolase family 38, central domain
Homologous_superfamily IPR011013 Galactose mutarotase-like domain superfamily
Homologous_superfamily IPR011330 Glycoside hydrolase/deacetylase, beta/alpha-barrel
Homologous_superfamily IPR013780 Glycosyl hydrolase, all-beta
Homologous_superfamily IPR027291 Glycoside hydrolase 38, N-terminal domain superfamily
Homologous_superfamily IPR028995 Glycoside hydrolase families 57/38, central domain superfamily
Homologous_superfamily IPR037094 Glycoside hydrolase family 38, central domain superfamily
Domain Details Per Protein
Protein Length Galactose mutarotase-like domain superfamily Glycoside hydrolase 38, N-terminal domain superfamily Glycoside hydrolase/deacetylase, beta/alpha-barrel Glycoside hydrolase families 57/38, central domain superfamily Glycoside hydrolase family 38, central domain Glycoside hydrolase family 38, central domain superfamily Glycoside hydrolase family 38, N-terminal domain Glycosyl hydrolase, all-beta Glycosyl hydrolase family 38, C-terminal
UniProtKB:E7EYL2 1151
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations