Gene

smoc1

ID
ZDB-GENE-110310-7
Name
SPARC related modular calcium binding 1
Symbol
smoc1 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to have calcium ion binding activity and extracellular matrix binding activity. Involved in optic cup morphogenesis involved in camera-type eye development. Human ortholog(s) of this gene implicated in microphthalmia with limb anomalies. Is expressed in brain; head; optic cup; and optic vesicle. Orthologous to human SMOC1 (SPARC related modular calcium binding 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from 2 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With smoc1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
microphthalmia with limb anomalies Alliance Microphthalmia with limb anomalies 206920
Associated With smoc1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Binding_site IPR018247 EF-Hand 1, calcium-binding site
Domain IPR000716 Thyroglobulin type-1
Domain IPR002350 Kazal domain
Domain IPR019577 SPARC/Testican, calcium-binding domain
Domain IPR037639 SMOC-1, extracellular calcium-binding domain
Homologous_superfamily IPR011992 EF-hand domain pair
Homologous_superfamily IPR036058 Kazal domain superfamily
Homologous_superfamily IPR036857 Thyroglobulin type-1 superfamily
Domain Details Per Protein
Protein Length EF-Hand 1, calcium-binding site EF-hand domain pair Kazal domain Kazal domain superfamily SMOC-1, extracellular calcium-binding domain SPARC/Testican, calcium-binding domain Thyroglobulin type-1 Thyroglobulin type-1 superfamily
UniProtKB:E7EDQ9 461
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations