Gene

akt3b

ID
ZDB-GENE-110309-3
Name
v-akt murine thymoma viral oncogene homolog 3b
Symbol
akt3b Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 1 Mapping Details/Browsers
Description
Predicted to enable ATP binding activity; protein serine kinase activity; and protein serine/threonine kinase activity. Predicted to act upstream of or within intracellular signal transduction and protein phosphorylation. Used to study schizophrenia. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
2 figures from Thyme et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With akt3b Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 615937
Associated With akt3b Via Experimental Models
Human Disease Fish Conditions Citations
schizophrenia akt3ba230/a230 standard conditions Thyme et al., 2019
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Active_site IPR008271 Serine/threonine-protein kinase, active site
Binding_site IPR017441 Protein kinase, ATP binding site
Domain IPR000719 Protein kinase domain
Domain IPR000961 AGC-kinase, C-terminal
Domain IPR001849 Pleckstrin homology domain
Domain IPR017892 Protein kinase, C-terminal
Domain IPR039026 Protein Kinase B, pleckstrin homology domain
Family IPR039029 Serine/threonine-protein kinase RAC gamma-like
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Homologous_superfamily IPR011993 PH-like domain superfamily
Domain Details Per Protein
Protein Length AGC-kinase, C-terminal PH-like domain superfamily Pleckstrin homology domain Protein kinase, ATP binding site Protein Kinase B, pleckstrin homology domain Protein kinase, C-terminal Protein kinase domain Protein kinase-like domain superfamily Serine/threonine-protein kinase, active site Serine/threonine-protein kinase RAC gamma-like
UniProtKB:E7EXT6 479
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations