ZFIN ID: ZDB-GENE-110309-3
Gene Name: v-akt murine thymoma viral oncogene homolog 3b
Gene Symbol: akt3b    Nomenclature History

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Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in intracellular signal transduction and protein phosphorylation. Used to study schizophrenia. Human ortholog(s) of this gene implicated in colon cancer; glioblastoma multiforme; prostate adenocarcinoma; prostate cancer; and renal cell carcinoma. Orthologous to human AKT3 (AKT serine/threonine kinase 3).
Genome Resources: Alliance (1),  Gene:100149794 (1),  Ensembl(GRCz11):ENSDARG00000087205 (2)
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Hatching:Long-pec (48.0h-60.0h) to Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
a230 Complex Unknown Unknown CRISPR
zko1068a Indel Unknown Unknown CRISPR
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-akt3b 1
CRISPR2-akt3b 1
CRISPR3-akt3b 1
CRISPR4-akt3b 1
CRISPR5-akt3b 1
DISEASE ASSOCIATED WITH akt3b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 615937
DISEASE ASSOCIATED WITH akt3b VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
schizophrenia akt3ba230/a230 standard conditions Thyme et al., 2019
GENE ONTOLOGY
Ontology GO Term
Biological Process intracellular signal transduction (more)
Molecular Function ATP binding (more)
GO Terms (all 10)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA akt3b-201 (1)    Ensembl 2276
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM akt3b No data available
MARKER RELATIONSHIPS
akt3b Contained in: [Fosmid] ZFOS-1868E3 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_001923419 (1)
Genomic GenBank:CU928197 (1) 36269 nt
Select Tool
Polypeptide UniProtKB:E7EXT6 (1) 479 aa
Sequence Information (all 8)
ORTHOLOGY for akt3b ( Chr: 1 )
CITATIONS (17)