ZFIN ID: ZDB-GENE-110221-1
Gene Name: klotho
Gene Symbol: kl    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have beta-glucosidase activity; fibroblast growth factor binding activity; and fibroblast growth factor receptor binding activity. Predicted to be involved in fibroblast growth factor receptor signaling pathway. Predicted to localize to extracellular space and integral component of membrane. Is expressed in several structures, including digestive system; gill; heart; pleuroperitoneal region; and yolk syncytial layer. Human ortholog(s) of this gene implicated in Prinzmetal angina; coronary artery disease; intracranial embolism; and spondylosis. Orthologous to human KL (klotho).
Genome Resources: Alliance (1),  Gene:562316 (1),  Ensembl(GRCz11):ENSDARG00000079862 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12515 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18644 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41699 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa41700 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-kl
    1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH kl HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    ?Tumoral calcinosis, hyperphosphatemic, familial, 3 617994
    DISEASE ASSOCIATED WITH kl VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process aging (more)
    Cellular Component extracellular space (more)
    Molecular Function hydrolase activity, hydrolyzing O-glycosyl compounds (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kl-202 (1)    Ensembl 3591
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kl No data available
    MARKER RELATIONSHIPS
    kl Contained in: [BAC] DKEY-10B15 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_021479418 (1)
    Genomic GenBank:BX548044 (1) 250011 nt Blast at MegaBLAST
    Polypeptide UniProtKB:F1RC43 (1) 990 aa
    Sequence Information (all 10)
    ORTHOLOGY for kl ( Chr: 10 )
    CITATIONS (21)