Gene
p2ry12
- ID
- ZDB-GENE-110208-4
- Name
- purinergic receptor P2Y12
- Symbol
- p2ry12 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 15 Mapping Details/Browsers
- Description
- Predicted to enable G protein-coupled purinergic nucleotide receptor activity. Acts upstream of or within microglial cell activation and regulation of primitive erythrocyte differentiation. Predicted to be located in plasma membrane. Is expressed in axial blood vessel; head; and hematopoietic system. Human ortholog(s) of this gene implicated in asthma; cerebrovascular disease; peripheral artery disease; platelet-type bleeding disorder 8; and type 2 diabetes mellitus. Orthologous to human P2RY12 (purinergic receptor P2Y12).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 7 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 5 figures from Li et al., 2020
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| platelet-type bleeding disorder 8 | Alliance | Bleeding disorder, platelet-type, 8 | 609821 |
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | GPCR, rhodopsin-like, 7TM | G protein-coupled receptor, rhodopsin-like | P2Y12 purinoceptor |
|---|---|---|---|---|---|
| UniProtKB:E7F2G6 | InterPro | 345 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
p2ry12-201
(1)
|
Ensembl | 1,308 nt | ||
| mRNA |
p2ry12-202
(1)
|
Ensembl | 1,371 nt |
Interactions and Pathways
No data available
Plasmids
No data available