Gene

nup214

ID
ZDB-GENE-110203-3
Name
nucleoporin 214
Symbol
nup214 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 5 Mapping Details/Browsers
Description
Predicted to have nuclear localization sequence binding activity. Predicted to be involved in RNA export from nucleus and protein import into nucleus. Predicted to localize to nuclear pore. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia; acute myeloid leukemia; and brain disease. Orthologous to human NUP214 (nucleoporin 214).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Kindermann et al., 2019
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
3 figures from Kindermann et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nup214 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
acute lymphoblastic leukemia Alliance Leukemia, T-cell acute lymphoblastic, somatic 613065
acute myeloid leukemia Alliance Leukemia, acute myeloid, somatic 601626
{Encephalopathy, acute, infection-induced, susceptibility to, 9} 618426
Associated With nup214 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR041553 Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain
Family IPR026054 Nuclear pore complex protein
Homologous_superfamily IPR015943 WD40/YVTN repeat-like-containing domain superfamily
Repeat IPR001680 WD40 repeat
Domain Details Per Protein
Protein Length Nuclear pore complex protein Nuclear pore complex protein Nup214, phenylalanine-glycine (FG) domain WD40 repeat WD40/YVTN repeat-like-containing domain superfamily
UniProtKB:E7F5M0 1218
UniProtKB:A5PLH2 480
UniProtKB:A0A0H2UKK7 1179
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations