ZFIN ID: ZDB-GENE-110114-3
Gene Name: cytochrome P450, family 2, subfamily AA, polypeptide 11
Gene Symbol: cyp2aa11    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 23 Mapping Details/Browsers
Description: Predicted to have heme binding activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen; and steroid hydroxylase activity. Predicted to be involved in several processes, including exogenous drug catabolic process; organic acid metabolic process; and xenobiotic metabolic process. Predicted to localize to the cytoplasm and intracellular membrane-bounded organelle. Human ortholog(s) of this gene implicated in acute myeloid leukemia; asthma; autoimmune hepatitis; precursor lymphoblastic lymphoma/leukemia; and rhinitis. Orthologous to human CYP2D6 (cytochrome P450 family 2 subfamily D member 6).
Genome Resources: Alliance (1),  Gene:553537 (1),  Ensembl(GRCz11):ENSDARG00000103456 (1)
GENE EXPRESSION
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH cyp2aa11 HUMAN ORTHOLOG No data available
DISEASE ASSOCIATED WITH cyp2aa11 VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process oxidation-reduction process (more)
Cellular Component integral component of membrane (more)
Molecular Function heme binding (more)
GO Terms (all 16)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Conserved_site IPR017972 Cytochrome P450, conserved site
Family IPR001128 Cytochrome P450
Family IPR002401 Cytochrome P450, E-class, group I
Family IPR008069 Cytochrome P450, E-class, group I, CYP2D-like
Homologous_superfamily IPR036396 Cytochrome P450 superfamily
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM cyp2aa11 No data available
MARKER RELATIONSHIPS No data available
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_017353668 (1)
Polypeptide UniProtKB:A0A0R4ISJ6 (1) 501 aa
Sequence Information (all 7)
ORTHOLOGY for cyp2aa11 ( Chr: 23 )
CITATIONS (15)