| ZFIN ID: ZDB-GENE-101209-2 |
| Gene Name: | potassium large conductance calcium-activated channel, subfamily M, alpha member 1b | |||||||||||||
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| Gene Symbol: | kcnma1b Nomenclature History |
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| Previous Name: | slo1b (1) | |||||||||||||
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| Gene Type: | protein_coding_gene | |||||||||||||
| Location: | Chr: 12 Mapping Details/Browsers | |||||||||||||
| Description: | Predicted to have large conductance calcium-activated potassium channel activity. Involved in response to auditory stimulus. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease and idiopathic generalized epilepsy. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1). | |||||||||||||
| Genome Resources: | Alliance (1), Gene:798583 (1) | |||||||||||||
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
| Targeting Reagent | Created Alleles | Publications |
|---|---|---|
| MO1-kcnma1b | N/A | 1 |
PHENOTYPE
| Data: | 2 figures from Rohmann et al., 2014 |
| Observed in: |
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Cerebellar atrophy, developmental delay, and seizures | 617643 | ||
| Liang-Wang syndrome | 618729 | ||
| Paroxysmal nonkinesigenic dyskinesia, 3, with or without generalized epilepsy | 609446 | ||
| {Epilepsy, idiopathic generalized, susceptibility to, 16} | 618596 |
GENE ONTOLOGY
| Ontology | GO Term |
|---|---|
| Biological Process | response to auditory stimulus (more) |
| Cellular Component | integral component of membrane (more) |
| Molecular Function | large conductance calcium-activated potassium channel activity (more) |
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES
No data available
PLASMIDS
No data available
CONSTRUCTS WITH SEQUENCES FROM kcnma1b
No data available
MARKER RELATIONSHIPS
No data available
SEQUENCE INFORMATION
| Type | Accession # | Length (nt/aa) | Analysis |
|---|---|---|---|
| RNA | RefSeq:XM_021480452 (1) |
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| Polypeptide | UniProtKB:B7TLZ1 (1) | 206 aa |
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ORTHOLOGY for kcnma1b (
Chr:
12
)
CITATIONS (11)