ZFIN ID: ZDB-GENE-101209-2
Gene Name: potassium large conductance calcium-activated channel, subfamily M, alpha member 1b
Gene Symbol: kcnma1b    Nomenclature History

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Previous Name: slo1b (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have large conductance calcium-activated potassium channel activity. Involved in response to auditory stimulus. Predicted to localize to integral component of membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease and idiopathic generalized epilepsy. Orthologous to human KCNMA1 (potassium calcium-activated channel subfamily M alpha 1).
Genome Resources: Alliance (1),  Gene:798583 (1)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-kcnma1b N/A 1
DISEASE ASSOCIATED WITH kcnma1b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Cerebellar atrophy, developmental delay, and seizures 617643
Liang-Wang syndrome 618729
Paroxysmal nonkinesigenic dyskinesia, 3, with or without generalized epilepsy 609446
{Epilepsy, idiopathic generalized, susceptibility to, 16} 618596
DISEASE ASSOCIATED WITH kcnma1b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process response to auditory stimulus (more)
Cellular Component integral component of membrane (more)
Molecular Function large conductance calcium-activated potassium channel activity (more)
GO Terms (all 5)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM kcnma1b No data available
MARKER RELATIONSHIPS No data available
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_021480452 (1)
Polypeptide UniProtKB:B7TLZ1 (1) 206 aa
Sequence Information (all 6)
ORTHOLOGY for kcnma1b ( Chr: 12 )
CITATIONS (11)