ZFIN ID: ZDB-GENE-101208-3
Gene Name: mitochondrial poly(A) polymerase
Gene Symbol: mtpap    Nomenclature History

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Previous Name: TUTase 1 (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 12 Mapping Details/Browsers
Description: Predicted to have polynucleotide adenylyltransferase activity. Predicted to be involved in mRNA polyadenylation. Predicted to localize to mitochondrion. Is expressed in head; ovary; and testis. Human ortholog(s) of this gene implicated in spastic ataxia 4. Orthologous to human MTPAP (mitochondrial poly(A) polymerase).
Genome Resources: Alliance (1),  Gene:563801 (1),  Ensembl(GRCz11):ENSDARG00000076155 (1)
GENE EXPRESSION
All Expression Data: Fig. S7 from Kamminga et al., 2010
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa38890 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH mtpap HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    spastic ataxia 4 Alliance ?Spastic ataxia 4, autosomal recessive 613672
    DISEASE ASSOCIATED WITH mtpap VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process mRNA polyadenylation (more)
    Cellular Component cytoplasm (more)
    Molecular Function nucleotidyltransferase activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA mtpap-201 (1)    Ensembl 2356
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM mtpap No data available
    MARKER RELATIONSHIPS
    mtpap Contained in: [BAC] CH211-39L20, DKEY-110M20 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_021480322 (1)
    Genomic GenBank:BX511144 185993 nt
    Select Tool
    Polypeptide UniProtKB:E7FEW2 (1) 600 aa
    Sequence Information (all 10)
    ORTHOLOGY for mtpap ( Chr: 12 )
    CITATIONS (16)