Gene

mtrr

ID
ZDB-GENE-101115-3
Name
5-methyltetrahydrofolate-homocysteine methyltransferase reductase
Symbol
mtrr Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to have coenzyme binding activity and oxidoreductase activity. Predicted to be involved in homocysteine metabolic process and methionine biosynthetic process. Predicted to localize to cytosol. Used to study visceral heterotaxy. Human ortholog(s) of this gene implicated in several diseases, including endocrine gland cancer (multiple); heart disease (multiple); hematologic cancer (multiple); homocystinuria; and ulcerative colitis. Orthologous to human MTRR (5-methyltetrahydrofolate-homocysteine methyltransferase reductase).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Burkhalter et al., 2019
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Burkhalter et al., 2019
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With mtrr Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
homocystinuria-megaloblastic anemia cblE type Alliance Homocystinuria-megaloblastic anemia, cbl E type 236270
neural tube defect Alliance {Neural tube defects, folate-sensitive, susceptibility to} 601634
Associated With mtrr Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001094 Flavodoxin-like
Domain IPR001433 Oxidoreductase FAD/NAD(P)-binding
Domain IPR001709 Flavoprotein pyridine nucleotide cytochrome reductase
Domain IPR003097 Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
Domain IPR008254 Flavodoxin/nitric oxide synthase
Domain IPR017927 FAD-binding domain, ferredoxin reductase-type
Homologous_superfamily IPR017938 Riboflavin synthase-like beta-barrel
Homologous_superfamily IPR023173 NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily
Homologous_superfamily IPR029039 Flavoprotein-like superfamily
Homologous_superfamily IPR039261 Ferredoxin-NADP reductase (FNR), nucleotide-binding domain
Domain Details Per Protein
Protein Length FAD-binding domain, ferredoxin reductase-type Ferredoxin-NADP reductase (FNR), nucleotide-binding domain Flavodoxin-like Flavodoxin/nitric oxide synthase Flavoprotein-like superfamily Flavoprotein pyridine nucleotide cytochrome reductase NADPH-cytochrome p450 reductase, FAD-binding, alpha-helical domain superfamily Oxidoreductase FAD/NAD(P)-binding Riboflavin synthase-like beta-barrel Sulfite reductase [NADPH] flavoprotein alpha-component-like, FAD-binding
UniProtKB:Q4V8W4 717
UniProtKB:Q0V954 480
UniProtKB:F8W423 182
UniProtKB:Q1RM95 190
UniProtKB:A0A2R8QQ95 711
UniProtKB:A0A0R4IZR6 695
UniProtKB:F1RE28 697
UniProtKB:A0A0R4IWY4 211
UniProtKB:F8W4Q3 442
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations