Gene

hecw2b

ID

ZDB-GENE-101001-3

Name

HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2b

Symbol

hecw2b Nomenclature History

Previous Names

nedl2b (1)

Type

protein_coding_gene

Location

Chr: 1 Mapping Details/Browsers

Description

Predicted to have ubiquitin-protein transferase activity. Orthologous to human HECW2 (HECT, C2 and WW domain containing E3 ubiquitin protein ligase 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With hecw2b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Neurodevelopmental disorder with hypotonia, seizures, and absent language	617268

Associated With hecw2b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000008	C2 domain
Domain	IPR000569	HECT domain
Domain	IPR001202	WW domain
Domain	IPR032348	E3 ubiquitin-protein ligase HECW1/2, N-terminal
Domain	IPR037795	E3 ubiquitin-protein ligase HECW, C2 domain
Domain	IPR040524	E3 ubiquitin-protein ligase HECW1, helical box domain
Homologous_superfamily	IPR035892	C2 domain superfamily
Homologous_superfamily	IPR035983	HECT, E3 ligase catalytic domain
Homologous_superfamily	IPR036020	WW domain superfamily

Domain Details Per Protein

Protein	Length	C2 domain	C2 domain superfamily	E3 ubiquitin-protein ligase HECW1/2, N-terminal	E3 ubiquitin-protein ligase HECW1, helical box domain	E3 ubiquitin-protein ligase HECW, C2 domain	HECT domain	HECT, E3 ligase catalytic domain	WW domain	WW domain superfamily
UniProtKB:A0A8M1RSA0 InterPro	1472

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	hecw2b-201 (1) Ensembl	Havana	1350 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance

Citations