ZFIN ID: ZDB-GENE-100922-142
Gene Name: rubicon autophagy regulator
Gene Symbol: rubcn    Nomenclature History

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Previous Names: si:ch1073-167a23.1, si:ch1073-280h16.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 22 Mapping Details/Browsers
Description: Predicted to have phosphatidylinositol phosphate binding activity. Predicted to be involved in negative regulation of autophagosome maturation; negative regulation of endocytosis; and negative regulation of phosphatidylinositol 3-kinase activity. Predicted to localize to early endosome; intracellular membrane-bounded organelle; and late endosome. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 15. Orthologous to human RUBCN (rubicon autophagy regulator).
Genome Resources: Alliance (1),  Gene:100000896 (1),  Ensembl(GRCz11):ENSDARG00000078752 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la014252Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • la022352Tg Transgenic Insertion Unknown Unknown DNA
    la028450Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa11314 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa12122 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24212 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-rubcn N/A 1
    MO2-rubcn N/A 2
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH rubcn HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive spinocerebellar ataxia 15 Alliance Spinocerebellar ataxia, autosomal recessive 15 615705
    DISEASE ASSOCIATED WITH rubcn VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process autophagy (more)
    Cellular Component endosome (more)
    Molecular Function phosphatidylinositol phosphate binding (more)
    GO Terms (all 10)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA rubcn-201 (1)    Ensembl 3007
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rubcn No data available
    MARKER RELATIONSHIPS
    rubcn Contained in: [Fosmid] CH1073-167A23 (1), CH1073-280H16 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005174059 (1) 4647 nt
    Genomic GenBank:CU480913 (1) 41139 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8Q663 (1) 956 aa
    Sequence Information (all 17)
    ORTHOLOGY for rubcn ( Chr: 22 )
    CITATIONS (20)