Gene

itgb6

ID
ZDB-GENE-100812-2
Name
integrin, beta 6
Symbol
itgb6 Nomenclature History
Previous Names
  • im:7165241
Type
protein_coding_gene
Location
Chr: 11 Mapping Details/Browsers
Description
Predicted to enable integrin binding activity. Predicted to be involved in several processes, including cell adhesion mediated by integrin; cell-matrix adhesion; and integrin-mediated signaling pathway. Predicted to act upstream of or within cell adhesion. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of integrin alphav-beta6 complex. Predicted to be active in cell surface and focal adhesion. Is expressed in several structures, including adaxial cell; liver; musculature system; otic vesicle; and sensory system. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1H. Orthologous to human ITGB6 (integrin subunit beta 6).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
7 figures from 2 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With itgb6 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
amelogenesis imperfecta type 1H Alliance Amelogenesis imperfecta, type IH 616221
Associated With itgb6 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR002369 Integrin beta subunit, VWA domain
Domain IPR012896 Integrin beta subunit, tail
Domain IPR013111 EGF-like domain, extracellular
Domain IPR014836 Integrin beta subunit, cytoplasmic domain
Domain IPR016201 PSI domain
Domain IPR033760 Integrin beta N-terminal
Domain IPR040622 Integrin beta, epidermal growth factor-like domain 1
Family IPR015436 Integrin beta-6 subunit
Family IPR015812 Integrin beta subunit
Homologous_superfamily IPR032695 Integrin domain superfamily
Homologous_superfamily IPR036349 Integrin beta tail domain superfamily
Homologous_superfamily IPR036465 von Willebrand factor A-like domain superfamily
Domain Details Per Protein
Protein Length EGF-like domain, extracellular Integrin beta-6 subunit Integrin beta, epidermal growth factor-like domain 1 Integrin beta N-terminal Integrin beta subunit Integrin beta subunit, cytoplasmic domain Integrin beta subunit, tail Integrin beta subunit, VWA domain Integrin beta tail domain superfamily Integrin domain superfamily PSI domain von Willebrand factor A-like domain superfamily
UniProtKB:F1QGX0 782
UniProtKB:A7MC25 303
UniProtKB:A0A0R4IP79 216
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations