Gene
c4b
- ID
- ZDB-GENE-100805-2
- Name
- complement C4B (Chido/Rodgers blood group)
- Symbol
- c4b Nomenclature History
- Previous Names
-
- c4-2 (1)
- c4bl
- si:dkey-8k3.2
- Type
- protein_coding_gene
- Location
- Chr: 16 Mapping Details/Browsers
- Description
- Predicted to enable endopeptidase inhibitor activity. Predicted to be involved in complement activation. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Human ortholog(s) of this gene implicated in autistic disorder; autoimmune disease (multiple); complement deficiency (multiple); and renal cell carcinoma. Orthologous to several human genes including C4B (complement C4B (Chido/Rodgers blood group)).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| complement component 4b deficiency | Alliance | C4B deficiency | 614379 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR019742 | Alpha-2-macroglobulin, conserved site |
| Conserved_site | IPR047565 | Alpha-macroglobulin-like, thiol-ester bond-forming region |
| Domain | IPR000020 | Anaphylatoxin/fibulin |
| Domain | IPR001134 | Netrin domain |
| Domain | IPR001599 | Alpha-2-macroglobulin |
| Domain | IPR002890 | Macroglobulin domain |
| Domain | IPR009048 | Alpha-macroglobulin, receptor-binding |
| Domain | IPR011625 | Alpha-2-macroglobulin, bait region domain |
| Domain | IPR011626 | Alpha-macroglobulin-like, TED domain |
| Domain | IPR018933 | Netrin module, non-TIMP type |
| Domain | IPR040839 | Macroglobulin domain MG4 |
| Domain | IPR041555 | Macroglobulin domain MG3 |
| Family | IPR050473 | Alpha-2-macroglobulin/Complement system |
| Homologous_superfamily | IPR008930 | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid |
| Homologous_superfamily | IPR008964 | Invasin/intimin cell-adhesion fragments |
| Homologous_superfamily | IPR008993 | Tissue inhibitor of metalloproteinases-like, OB-fold |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR018081 | Anaphylatoxin, complement system |
| Homologous_superfamily | IPR036595 | Alpha-macroglobulin, receptor-binding domain superfamily |
Domain Details Per Protein
| Protein | Additional Resources | Length | Alpha-2-macroglobulin | Alpha-2-macroglobulin, bait region domain | Alpha-2-macroglobulin/Complement system | Alpha-2-macroglobulin, conserved site | Alpha-macroglobulin-like, TED domain | Alpha-macroglobulin-like, thiol-ester bond-forming region | Alpha-macroglobulin, receptor-binding | Alpha-macroglobulin, receptor-binding domain superfamily | Anaphylatoxin, complement system | Anaphylatoxin/fibulin | Immunoglobulin-like fold | Invasin/intimin cell-adhesion fragments | Macroglobulin domain | Macroglobulin domain MG3 | Macroglobulin domain MG4 | Netrin domain | Netrin module, non-TIMP type | Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid | Tissue inhibitor of metalloproteinases-like, OB-fold |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0AB13A3K7 | InterPro | 1717 |
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| aberrant processed transcript |
si:dkey-8k3.2-201
(1)
|
Ensembl | 866 nt | ||
| mRNA |
si:dkey-8k3.2-202
(1)
|
Ensembl | 5,339 nt | ||
| ncRNA |
ottdart00000052435
(1)
|
Ensembl | 760 nt |
Interactions and Pathways
No data available
Plasmids
No data available