ZFIN ID: ZDB-GENE-100805-1
Gene Name: adenylate cyclase 1b
Gene Symbol: adcy1b    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 2 Mapping Details/Browsers
Description: Predicted to have adenylate cyclase activity. Involved in axon midline choice point recognition; retinal ganglion cell axon guidance; and sensory perception of sound. Predicted to localize to integral component of plasma membrane. Human ortholog(s) of this gene implicated in autosomal recessive nonsyndromic deafness 44. Orthologous to human ADCY1 (adenylate cyclase 1).
Genome Resources: Alliance (1),  Gene:569499 (1),  Ensembl(GRCz11):ENSDARG00000088634 (2)
GENE EXPRESSION
All Expression Data: Fig. S1 from Xu et al., 2010
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6821 Point Mutation Unknown Splice Site ENU
sa19643 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32815 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-adcy1b N/A 2
    MO2-adcy1b N/A 1
    DISEASE ASSOCIATED WITH adcy1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal recessive nonsyndromic deafness 44 Alliance ?Deafness, autosomal recessive 44 610154
    DISEASE ASSOCIATED WITH adcy1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process axon midline choice point recognition (more)
    Cellular Component integral component of membrane (more)
    Molecular Function adenylate cyclase activity (more)
    GO Terms (all 18)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA adcy1b-202 (1)    Ensembl 1547
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM adcy1b No data available
    MARKER RELATIONSHIPS
    adcy1b Contained in: [Fosmid] CH1073-443F24 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:NM_001168350 (1) 3385 nt
    Genomic GenBank:CU693452 (1) 32999 nt
    Select Tool
    Polypeptide UniProtKB:D1MIA3 (1) 1114 aa
    Sequence Information (all 12)
    ORTHOLOGY for adcy1b ( Chr: 2 )
    CITATIONS (20)