Gene
dock3
- ID
- ZDB-GENE-100624-1
- Name
- dedicator of cytokinesis 3
- Symbol
- dock3 Nomenclature History
- Previous Names
-
- si:ch211-216d10.1
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to have GTPase activator activity and guanyl-nucleotide exchange factor activity. Predicted to be involved in small GTPase mediated signal transduction. Human ortholog(s) of this gene implicated in attention deficit hyperactivity disorder. Orthologous to human DOCK3 (dedicator of cytokinesis 3).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| Neurodevelopmental disorder with impaired intellectual development, hypotonia, and ataxia | 618292 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001452 | SH3 domain |
| Domain | IPR026800 | Dedicator of cytokinesis protein 3, DHR2 domain |
| Domain | IPR027007 | C2 DOCK-type domain |
| Domain | IPR027357 | DOCKER domain |
| Domain | IPR032376 | Dedicator of cytokinesis, N-terminal domain |
| Domain | IPR037811 | Dedicator of cytokinesis B, C2 domain |
| Domain | IPR046769 | DOCKER, Lobe A |
| Domain | IPR046770 | DOCKER, Lobe B |
| Domain | IPR046773 | DOCKER, Lobe C |
| Family | IPR026791 | Dedicator of cytokinesis |
| Homologous_superfamily | IPR016024 | Armadillo-type fold |
| Homologous_superfamily | IPR035892 | C2 domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR042455 | Dedicator of cytokinesis, N-terminal, subdomain 1 |
| Homologous_superfamily | IPR043161 | Dedicator of cytokinesis, C-terminal, lobe A |
| Homologous_superfamily | IPR043162 | Dedicator of cytokinesis, C-terminal, lobe C |
Domain Details Per Protein
| Protein | Length | Armadillo-type fold | C2 DOCK-type domain | C2 domain superfamily | Dedicator of cytokinesis | Dedicator of cytokinesis B, C2 domain | Dedicator of cytokinesis, C-terminal, lobe A | Dedicator of cytokinesis, C-terminal, lobe C | Dedicator of cytokinesis, N-terminal domain | Dedicator of cytokinesis, N-terminal, subdomain 1 | Dedicator of cytokinesis protein 3, DHR2 domain | DOCKER domain | DOCKER, Lobe A | DOCKER, Lobe B | DOCKER, Lobe C | SH3 domain | SH3-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M9P4T5
|
1906 | ||||||||||||||||
|
UniProtKB:A0A8M3AXY0
|
2070 | ||||||||||||||||
|
UniProtKB:A0A8M6Z3K1
|
2068 | ||||||||||||||||
|
UniProtKB:A0A8M9PSK3
|
1924 | ||||||||||||||||
|
UniProtKB:A0A8M6YXG5
|
2108 | ||||||||||||||||
|
UniProtKB:A0A8M3B5S0
|
2094 | ||||||||||||||||
|
UniProtKB:A0A8M3AMH0
|
2101 | ||||||||||||||||
|
UniProtKB:A0A8M6YVP8
|
2069 | ||||||||||||||||
|
UniProtKB:A0A8M6YV41
|
2077 | ||||||||||||||||
|
UniProtKB:A0A8M3AN91
|
2087 | ||||||||||||||||
|
UniProtKB:A0A8M3AXX4
|
1990 | ||||||||||||||||
|
UniProtKB:A0A8M6Z4A0
|
2099 | ||||||||||||||||
|
UniProtKB:A0A8M3AUX0
|
2107 |
Interactions and Pathways
No data available
Plasmids
No data available