ZFIN ID: ZDB-GENE-100309-2
Gene Name: neuroligin 4 X-linked a
Gene Symbol: nlgn4xa    Nomenclature History

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Previous Names: nlgn4a, nlgn4b (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 1 Mapping Details/Browsers
Description: Predicted to have neurexin family protein binding activity and signaling receptor activity. Predicted to be involved in several processes, including neuron cell-cell adhesion; synapse assembly; and synaptic vesicle endocytosis. Predicted to localize to the cell surface; integral component of plasma membrane; and synapse. Human ortholog(s) of this gene implicated in Asperger syndrome and autistic disorder. Is expressed in several structures, including brain; eye; gonad; spinal cord interneuron; and swim bladder. Orthologous to several human genes including NLGN4X (neuroligin 4 X-linked).
Genome Resources: Alliance (1),  Gene:561122 (1),  Ensembl(GRCz11):ENSDARG00000079455 (2)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH nlgn4xa HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Mental retardation, X-linked 300495
{Asperger syndrome susceptibility, X-linked 2} 300497
{Autism susceptibility, X-linked 2} 300495
DISEASE ASSOCIATED WITH nlgn4xa VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process chemical synaptic transmission (more)
Cellular Component integral component of membrane (more)
Molecular Function neurexin family protein binding (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR000460 Neuroligin
Domain IPR002018 Carboxylesterase, type B
Conserved_site IPR019819 Carboxylesterase type B, conserved site
Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
TRANSCRIPTS No data available
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM nlgn4xa No data available
MARKER RELATIONSHIPS No data available
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001166331 (1) 2481 bp
Genomic GenBank:BX005249 (1) 154305 bp
Select Tool
Polypeptide UniProtKB:F1Q7W8 (1) 844 aa
Sequence Information (all 19)
ORTHOLOGY for nlgn4xa ( Chr: 1 )
CITATIONS (19)