ZFIN ID: ZDB-GENE-100309-1
Gene Name: neuroligin 4 X-linked b
Gene Symbol: nlgn4xb    Nomenclature History

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Previous Names: nlgn4a (1), nlgn4b

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Ambiguous Mapping Details/Browsers
Description: Predicted to have neurexin family protein binding activity and signaling receptor activity. Predicted to be involved in several processes, including neuron cell-cell adhesion; synapse assembly; and synaptic vesicle endocytosis. Predicted to localize to cell surface; integral component of plasma membrane; and synapse. Is expressed in several structures, including brain; cranial ganglion; eye; gonad; and swim bladder. Human ortholog(s) of this gene implicated in Asperger syndrome and autistic disorder. Orthologous to human NLGN4X (neuroligin 4 X-linked).
Genome Resources: Alliance (1),  Gene:100147967 (1),  Ensembl(GRCz11):ENSDARG00000077761 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
CRISPR1-nlgn4xb
2
PHENOTYPE No data available
DISEASE ASSOCIATED WITH nlgn4xb HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Mental retardation, X-linked 300495
{Asperger syndrome susceptibility, X-linked 2} 300497
{Autism susceptibility, X-linked 2} 300495
DISEASE ASSOCIATED WITH nlgn4xb VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process chemical synaptic transmission (more)
Cellular Component integral component of membrane (more)
Molecular Function neurexin family protein binding (more)
GO Terms (all 13)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA nlgn4xa-202 (1)    Ensembl 2532
nlgn4xa-203 (1)    Ensembl 4719
Browsers: NCBI
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM nlgn4xb No data available
MARKER RELATIONSHIPS
nlgn4xb Contained in: [BAC] CH73-137F8 (1), CH211-245K15 (1)
[Fosmid] CH1073-341H12 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001166337 (1) 2388 nt
Genomic GenBank:CU462859 (1) 153740 nt
Select Tool
Polypeptide UniProtKB:D0EVX3 (1) 795 aa
Sequence Information (all 22)
ORTHOLOGY for nlgn4xb ( Ambiguous )
CITATIONS (18)