Gene

nlgn4xb

ID
ZDB-GENE-100309-1
Name
neuroligin 4 X-linked b
Symbol
nlgn4xb Nomenclature History
Previous Names
  • nlgn4a (1)
  • nlgn4b
Type
protein_coding_gene
Location
Ambiguous Mapping Details/Browsers
Description
Predicted to have neurexin family protein binding activity and signaling receptor activity. Predicted to be involved in several processes, including neuron cell-cell adhesion; synapse assembly; and synaptic vesicle endocytosis. Predicted to localize to cell surface; integral component of plasma membrane; and synapse. Is expressed in several structures, including brain; cranial ganglion; eye; gonad; and swim bladder. Human ortholog(s) of this gene implicated in Asperger syndrome and autistic disorder. Orthologous to human NLGN4X (neuroligin 4 X-linked).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 3 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With nlgn4xb Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Mental retardation, X-linked 300495
{Asperger syndrome susceptibility, X-linked 2} 300497
{Autism susceptibility, X-linked 2} 300495
Associated With nlgn4xb Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR019819 Carboxylesterase type B, conserved site
Domain IPR002018 Carboxylesterase, type B
Family IPR000460 Neuroligin
Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
Domain Details Per Protein
Protein Length Alpha/Beta hydrolase fold Carboxylesterase, type B Carboxylesterase type B, conserved site Neuroligin
UniProtKB:F1QK81 795
UniProtKB:D2X2G5 795
UniProtKB:D0EVX3 795
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations