Gene

card11

ID
ZDB-GENE-100219-1
Name
caspase recruitment domain family, member 11
Symbol
card11 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 3 Mapping Details/Browsers
Description
Predicted to have CARD domain binding activity. Predicted to be involved in positive regulation of NF-kappaB transcription factor activity and regulation of apoptotic process. Predicted to localize to cytoplasm. Is expressed in gill; intestine; kidney; spleen; and unfertilized egg. Human ortholog(s) of this gene implicated in diffuse large B-cell lymphoma and primary immunodeficiency disease. Orthologous to human CARD11 (caspase recruitment domain family member 11).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Chang et al., 2010
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With card11 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
immunodeficiency 11A Alliance Immunodeficiency 11A 615206
immunodeficiency 11B Alliance Immunodeficiency 11B with atopic dermatitis 617638
B-cell expansion with NFKB and T-cell anergy 616452
Associated With card11 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR001315 CARD domain
Family IPR033538 Caspase recruitment domain-containing protein 11
Homologous_superfamily IPR011029 Death-like domain superfamily
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR036034 PDZ superfamily
Domain Details Per Protein
Protein Length CARD domain Caspase recruitment domain-containing protein 11 Death-like domain superfamily PDZ superfamily P-loop containing nucleoside triphosphate hydrolase
UniProtKB:X1WGE1 1110
UniProtKB:A0A2R8QGQ8 116
UniProtKB:E7FB52 290
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations