Gene

brcc3

ID
ZDB-GENE-100215-1
Name
BRCA1/BRCA2-containing complex, subunit 3
Symbol
brcc3 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to have metallopeptidase activity; polyubiquitin modification-dependent protein binding activity; and thiol-dependent ubiquitin-specific protease activity. Involved in angiogenesis. Predicted to localize to BRCA1-A complex and BRISC complex. Is expressed in axial vasculature and head. Orthologous to human BRCC3 (BRCA1/BRCA2-containing complex subunit 3).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
1 figure from Miskinyte et al., 2011
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Miskinyte et al., 2011
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With brcc3 Human Ortholog
No data available
Associated With brcc3 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR000555 JAB1/MPN/MOV34 metalloenzyme domain
Domain IPR037518 MPN domain
Domain IPR040749 BRCC36, C-terminal helical domain
Family IPR033860 Brcc36 isopeptidase
Domain Details Per Protein
Protein Length BRCC36, C-terminal helical domain Brcc36 isopeptidase JAB1/MPN/MOV34 metalloenzyme domain MPN domain
UniProtKB:A0A8M3B525 287
Transcripts
Genome Browsers
Type Name Annotation Method Length (nt) Analysis
mRNA brcc3-202 (1) Havana 1338 nt
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations