Gene
cyld2
- ID
- ZDB-GENE-100208-1
- Name
- cylindromatosis (turban tumor syndrome) 2
- Symbol
- cyld2 Nomenclature History
- Previous Names
-
- cyldb (1)
- Type
- protein_coding_gene
- Location
- Chr: 11 Mapping Details/Browsers
- Description
- Predicted to have thiol-dependent ubiquitinyl hydrolase activity. Involved in cranial skeletal system development. Human ortholog(s) of this gene implicated in Brooke-Spiegler syndrome. Orthologous to human CYLD (CYLD lysine 63 deubiquitinase).
- Genome Resources
- Note
-
03-Apr-2024 Examination of current data suggests this gene existed prior to the divergence of ray- and lobe-finned fishes; therefore, should not have a/b nomenclature
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR000938 | CAP Gly-rich domain |
| Domain | IPR001394 | Peptidase C19, ubiquitin carboxyl-terminal hydrolase |
| Domain | IPR028889 | Ubiquitin specific protease domain |
| Homologous_superfamily | IPR036859 | CAP Gly-rich domain superfamily |
| Homologous_superfamily | IPR038765 | Papain-like cysteine peptidase superfamily |
Domain Details Per Protein
| Protein | Length | CAP Gly-rich domain | CAP Gly-rich domain superfamily | Papain-like cysteine peptidase superfamily | Peptidase C19, ubiquitin carboxyl-terminal hydrolase | Ubiquitin specific protease domain |
|---|---|---|---|---|---|---|
|
UniProtKB:E7F048
|
694 |
Interactions and Pathways
No data available
Plasmids
No data available
- Comparative Orthology
- Alliance