ZFIN ID: ZDB-GENE-091231-1
Gene Name: potassium channel, subfamily T, member 1
Gene Symbol: kcnt1    Nomenclature History

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Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have intracellular sodium activated potassium channel activity and outward rectifier potassium channel activity. Predicted to be involved in potassium ion transport. Predicted to localize to integral component of membrane and plasma membrane. Human ortholog(s) of this gene implicated in autosomal dominant nocturnal frontal lobe epilepsy 5 and early infantile epileptic encephalopathy 14. Orthologous to human KCNT1 (potassium sodium-activated channel subfamily T member 1).
Genome Resources: Alliance (1),  Gene:100004419 (1),  Ensembl(GRCz11):ENSDARG00000079484 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12911 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23851 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa29503 Point Mutation Unknown Splice Site ENU
    sa43577 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH kcnt1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    autosomal dominant nocturnal frontal lobe epilepsy 5 Alliance Epilepsy, nocturnal frontal lobe, 5 615005
    early infantile epileptic encephalopathy 14 Alliance Epileptic encephalopathy, early infantile, 14 614959
    DISEASE ASSOCIATED WITH kcnt1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process potassium ion transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function intracellular sodium activated potassium channel activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kcnt1-202 (1)    Ensembl 3169
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kcnt1 No data available
    MARKER RELATIONSHIPS
    kcnt1 Contained in: [BAC] CH73-286L20 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_009295128 (1)
    Genomic GenBank:CU694955 (1) 94664 nt
    Select Tool
    Polypeptide UniProtKB:A0A2R8QB85 (1) 1125 aa
    Sequence Information (all 15)
    ORTHOLOGY for kcnt1 ( Chr: 21 )
    CITATIONS (17)