mhc2d8.37b2

ID

ZDB-GENE-091204-413

Name

major histocompatibility complex class II d8.37b2

Symbol

mhc2d8.37b2 Nomenclature History

Previous Names

mhc2d8.37b2p
si:zfos-2070c2.3 (1)

Type

protein_coding_gene

Location

Chr: 8 Mapping Details/Browsers

Genome Assembly

GRCz11

Annotation Status

Not in current annotation release

Description

Predicted to enable MHC class II protein complex binding activity and peptide antigen binding activity. Predicted to be involved in several processes, including antigen processing and presentation of exogenous peptide antigen via MHC class II; peptide antigen assembly with MHC class II protein complex; and positive regulation of T cell activation. Predicted to act upstream of or within antigen processing and presentation and immune response. Predicted to be located in membrane. Predicted to be part of MHC class II protein complex. Predicted to be active in late endosome membrane and lysosomal membrane. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); bacterial infectious disease (multiple); eye disease (multiple); and lung disease (multiple). Orthologous to several human genes including HLA-DOB (major histocompatibility complex, class II, DO beta); HLA-DPB1 (major histocompatibility complex, class II, DP beta 1); and HLA-DQB1 (major histocompatibility complex, class II, DQ beta 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With mhc2d8.37b2 Human Ortholog

No data available

Associated With mhc2d8.37b2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR000353	MHC class II, beta chain, N-terminal
Domain	IPR003597	Immunoglobulin C1-set
Domain	IPR007110	Immunoglobulin-like domain
Family	IPR050160	Major Histocompatibility Complex/Immunoglobulin
Homologous_superfamily	IPR011162	MHC classes I/II-like antigen recognition protein
Homologous_superfamily	IPR013783	Immunoglobulin-like fold
Homologous_superfamily	IPR014745	MHC class II, alpha/beta chain, N-terminal
Homologous_superfamily	IPR036179	Immunoglobulin-like domain superfamily