Gene

dnah5l

ID
ZDB-GENE-091204-287
Name
dynein, axonemal, heavy chain 5 like
Symbol
dnah5l Nomenclature History
Previous Names
  • fj04c06
  • si:dkeyp-87a6.1
  • wu:fj04c06
Type
protein_coding_gene
Location
Chr: 24 Mapping Details/Browsers
Description
Predicted to have ATP-dependent microtubule motor activity, minus-end-directed; dynein intermediate chain binding activity; and dynein light intermediate chain binding activity. Involved in determination of heart left/right asymmetry. Predicted to localize to outer dynein arm. Human ortholog(s) of this gene implicated in Kartagener syndrome and primary ciliary dyskinesia 3. Orthologous to human DNAH5 (dynein axonemal heavy chain 5) and DNAH8 (dynein axonemal heavy chain 8).
Genome Resources
Note
None
Expression
All Expression Data
1 figure from Yamaguchi et al., 2018
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With dnah5l Human Ortholog
No data available
Associated With dnah5l Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR006311 Twin-arginine translocation pathway, signal sequence
Domain IPR003593 AAA+ ATPase domain
Domain IPR004273 Dynein heavy chain region D6 P-loop domain
Domain IPR013594 Dynein heavy chain, domain-1
Domain IPR013602 Dynein heavy chain, domain-2
Domain IPR024317 Dynein heavy chain, AAA module D4
Domain IPR024743 Dynein heavy chain, coiled coil stalk
Domain IPR035699 Dynein heavy chain, hydrolytic ATP-binding dynein motor region
Domain IPR035706 Dynein heavy chain, ATP-binding dynein motor region
Domain IPR041228 Dynein heavy chain, C-terminal domain
Domain IPR041466 Dynein heavy chain, AAA 5 extension domain
Domain IPR041589 Dynein heavy chain 3, AAA+ lid domain
Domain IPR041658 Dynein heavy chain AAA lid domain
Family IPR026983 Dynein heavy chain
Homologous_superfamily IPR027417 P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily IPR042219 Dynein heavy chain AAA lid domain superfamily
Homologous_superfamily IPR042222 Dynein heavy chain, domain 2, N-terminal
Homologous_superfamily IPR042228 Dynein heavy chain, domain 2, C-terminal
Homologous_superfamily IPR043157 Dynein heavy chain, AAA1 domain, small subdomain
Homologous_superfamily IPR043160 Dynein heavy chain, C-terminal domain, barrel region
Domain Details Per Protein
Protein Length AAA+ ATPase domain Dynein heavy chain Dynein heavy chain 3, AAA+ lid domain Dynein heavy chain, AAA1 domain, small subdomain Dynein heavy chain, AAA 5 extension domain Dynein heavy chain AAA lid domain Dynein heavy chain AAA lid domain superfamily Dynein heavy chain, AAA module D4 Dynein heavy chain, ATP-binding dynein motor region Dynein heavy chain, coiled coil stalk Dynein heavy chain, C-terminal domain Dynein heavy chain, C-terminal domain, barrel region Dynein heavy chain, domain-1 Dynein heavy chain, domain-2 Dynein heavy chain, domain 2, C-terminal Dynein heavy chain, domain 2, N-terminal Dynein heavy chain, hydrolytic ATP-binding dynein motor region Dynein heavy chain region D6 P-loop domain P-loop containing nucleoside triphosphate hydrolase Twin-arginine translocation pathway, signal sequence
UniProtKB:E7FFM4 2685
UniProtKB:K7DY80 4442
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Citations