ZFIN ID: ZDB-GENE-091118-65
Gene Name: gamma-aminobutyric acid type A receptor subunit gamma2
Gene Symbol: gabrg2    Nomenclature History

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Previous Name: si:ch211-145n14.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Contributes to GABA-gated chloride ion channel activity. Involved in protein heterotrimerization. Predicted to localize to several cellular components, including GABA-A receptor complex; dendrite membrane; and postsynapse. Is expressed in central nervous system and eye. Human ortholog(s) of this gene implicated in childhood absence epilepsy; early infantile epileptic encephalopathy; and familial febrile seizures 8. Orthologous to human GABRG2 (gamma-aminobutyric acid type A receptor subunit gamma2).
Genome Resources: Alliance (1),  Ensembl(GRCz11):ENSDARG00000053665 (2)
GENE EXPRESSION
All Expression Data: 3 figures from 3 publications
Wild-type Stages, Structures: Larval:Days 7-13 (168.0h-14d, 4.5mm, 8 teeth) to Adult (90d-730d, breeding adult)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028368Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa17984 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa24028 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32358 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • udm302 Indel Unknown Unknown CRISPR
    Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-gabrg2 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH gabrg2 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    familial febrile seizures 8 Alliance Epilepsy, generalized, with febrile seizures plus, type 3 607681
    Febrile seizures, familial, 8 607681
    Epileptic encephalopathy, early infantile, 74 618396
    DISEASE ASSOCIATED WITH gabrg2 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process protein heterotrimerization (more)
    Cellular Component integral component of membrane (more)
    Molecular Function CONTRIBUTES_TO   GABA-gated chloride ion channel activity (more)
    GO Terms (all 31)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA gabrg2-201 (1)    Ensembl 1381
    Browsers: EnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM gabrg2 No data available
    MARKER RELATIONSHIPS
    gabrg2 Contained in: [BAC] CH211-145N14 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    Genomic GenBank:CR847531 (1) 150363 nt
    Select Tool
    Polypeptide UniProtKB:F1RDP2 (1) 477 aa
    Sequence Information (all 4)
    ORTHOLOGY for gabrg2 ( Chr: 21 )
    CITATIONS (30)