ZFIN ID: ZDB-GENE-091118-108
Gene Name: si:ch211-161h7.4
Gene Symbol: si:ch211-161h7.4    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have centromeric DNA binding activity. Predicted to be involved in attachment of mitotic spindle microtubules to kinetochore; kinetochore assembly; and monopolar spindle attachment to meiosis I kinetochore. Predicted to localize to condensed nuclear chromosome kinetochore. Human ortholog(s) of this gene implicated in CREST syndrome and liver cirrhosis. Orthologous to human CENPC (centromere protein C).
Genome Resources: Alliance (1),  Gene:569837 (1),  Ensembl(GRCz11):ENSDARG00000087238 (2)

Nomenclature Note: This gene is derived from the zebrafish genome sequencing and annotation project. When more is known about the gene, the current nomenclature will be replaced with more traditional zebrafish gene nomenclature. The prefix 'si:' indicates that this gene is represented by annotated genomic sequence from the Sanger Institute.

GENE EXPRESSION
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa44123 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH si:ch211-161h7.4 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH si:ch211-161h7.4 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process kinetochore assembly (more)
    Cellular Component kinetochore (more)
    Molecular Function centromeric DNA binding (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA si:ch211-161h7.4-201 (1)    Ensembl 4326
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM si:ch211-161h7.4 No data available
    MARKER RELATIONSHIPS
    si:ch211-161h7.4 Contained in: [BAC] CH211-161H7 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005162726 (1)
    Genomic GenBank:CR450812 (1) 154456 nt
    Select Tool
    Polypeptide UniProtKB:E7FAC3 (1) 1130 aa
    Sequence Information (all 9)
    ORTHOLOGY for si:ch211-161h7.4 ( Chr: 24 )
    CITATIONS (13)