Gene
pde8b
- ID
- ZDB-GENE-091117-3
- Name
- phosphodiesterase 8B
- Symbol
- pde8b Nomenclature History
- Previous Names
-
- si:dkeyp-1d11.1
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to enable 3',5'-cyclic-AMP phosphodiesterase activity and 3',5'-cyclic-GMP phosphodiesterase activity. Predicted to be involved in cAMP-mediated signaling and positive regulation of ERK1 and ERK2 cascade. Predicted to act upstream of or within regulation of DNA-templated transcription and signal transduction. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease 3. Orthologous to human PDE8B (phosphodiesterase 8B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa9848 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa9852 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa17719 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa19253 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa19254 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa29518 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa32333 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37231 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa37232 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa37233 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary pigmented nodular adrenocortical disease 3 | Alliance | Pigmented nodular adrenocortical disease, primary, 3 | 614190 |
| striatonigral degeneration | Alliance | Striatal degeneration, autosomal dominant | 609161 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Additional Resources | Length | 3'5'-cyclic nucleotide phosphodiesterase | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | 3'5'-cyclic nucleotide phosphodiesterase PDE8 | HD/PDEase domain | PAS domain | PAS domain superfamily | PAS fold |
|---|---|---|---|---|---|---|---|---|---|---|---|
| UniProtKB:A0A8M3AWN1 | InterPro | 874 | |||||||||
| UniProtKB:A0A8M9P3K9 | InterPro | 797 | |||||||||
| UniProtKB:A0A8M3ATN7 | InterPro | 788 |
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Interactions and Pathways
No data available
Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEYP-1D11 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:XM_009295180 (1) | |||
| Genomic | GenBank:CU459136 (1) | 159343 nt | ||
| Polypeptide | UniProtKB:A0A8M3AWN1 (1) | 874 aa |
- Wei, X.Y., Jia, P.P., Hu, H., Liu, L., Li, T.Y., Li, Y.Z., Pei, D.S. (2023) Multi-omics reveal mechanisms underlying chronic kidney disease of unknown etiology (CKDu) pathogenesis using zebrafish. Environmental pollution (Barking, Essex : 1987). 337:122524
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
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