Gene
pde8b
- ID
- ZDB-GENE-091117-3
- Name
- phosphodiesterase 8B
- Symbol
- pde8b Nomenclature History
- Previous Names
-
- si:dkeyp-1d11.1
- Type
- protein_coding_gene
- Location
- Chr: 21 Mapping Details/Browsers
- Description
- Predicted to have 3',5'-cyclic-AMP phosphodiesterase activity. Predicted to be involved in regulation of transcription, DNA-templated and signal transduction. Human ortholog(s) of this gene implicated in primary pigmented nodular adrenocortical disease. Orthologous to human PDE8B (phosphodiesterase 8B).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- No data available
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| primary pigmented nodular adrenocortical disease 3 | Alliance | Pigmented nodular adrenocortical disease, primary, 3 | 614190 |
| striatonigral degeneration | Alliance | Striatal degeneration, autosomal dominant | 609161 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Conserved_site | IPR023174 | 3'5'-cyclic nucleotide phosphodiesterase, conserved site |
| Domain | IPR000014 | PAS domain |
| Domain | IPR002073 | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain |
| Domain | IPR003607 | HD/PDEase domain |
| Domain | IPR013767 | PAS fold |
| Domain | IPR013938 | 3'5'-cyclic nucleotide phosphodiesterase PDE8 |
| Family | IPR023088 | 3'5'-cyclic nucleotide phosphodiesterase |
| Homologous_superfamily | IPR035965 | PAS domain superfamily |
| Homologous_superfamily | IPR036971 | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily |
Domain Details Per Protein
| Protein | Length | 3'5'-cyclic nucleotide phosphodiesterase | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain | 3'5'-cyclic nucleotide phosphodiesterase, catalytic domain superfamily | 3'5'-cyclic nucleotide phosphodiesterase, conserved site | 3'5'-cyclic nucleotide phosphodiesterase PDE8 | HD/PDEase domain | PAS domain | PAS domain superfamily | PAS fold |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A8M3AWN1
|
874 | |||||||||
|
UniProtKB:A0A8M9P3K9
|
797 | |||||||||
|
UniProtKB:A0A8M3ATN7
|
788 |
Interactions and Pathways
No data available
Plasmids
No data available