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General Information
ZIRC
ZFIN ID: ZDB-GENE-091117-1
Gene Name: neurofilament, light polypeptide a
Gene Symbol: nefla
Sequence Ontology ID : SO:0001217

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Previous Name: si:ch211-222n4.10 (1)

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(Including Attributions)
Location: Chr: 21 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have structural molecule activity. Predicted to localize to the intermediate filament. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease (multiple); amyotrophic  ...
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa12368 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa45733 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: Fig. 4 from Wang et al., 2018
    Observed in:
    DISEASE ASSOCIATED WITH nefla HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    Charcot-Marie-Tooth disease dominant intermediate G Charcot-Marie-Tooth disease, dominant intermediate G 617882
    Charcot-Marie-Tooth disease type 1F Charcot-Marie-Tooth disease, type 1F 607734
    Charcot-Marie-Tooth disease type 2E Charcot-Marie-Tooth disease, type 2E 607684
    DISEASE ASSOCIATED WITH nefla VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Cellular Component intermediate filament (more)
    GO Terms (all 1)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA nefla-202 (1) 1848
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nefla No data available
    MARKER RELATIONSHIPS
    nefla Contained in: [BAC] CH211-222N4 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_021469060 (1)
    Genomic GenBank:CU467622 (1) 128877 bp
    Select Tool
    Polypeptide UniProtKB:E9QFD5 (1) 616 aa
    Sequence Information (all 7)
    ORTHOLOGY for nefla ( Chr: 21 )
    CITATIONS (15)