ZFIN ID: ZDB-GENE-091116-14
Gene Name: ATPase phospholipid transporting 8B1
Gene Symbol: atp8b1    Nomenclature History

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Previous Name: si:ch211-180b7.2

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have ATPase-coupled intramembrane lipid transporter activity. Predicted to be involved in Golgi organization and phospholipid translocation. Predicted to localize to the Golgi apparatus and plasma membrane. Human ortholog(s) of this gene implicated in benign recurrent intrahepatic cholestasis 1; intrahepatic cholestasis; intrahepatic cholestasis of pregnancy 1; and progressive familial intrahepatic cholestasis 1. Orthologous to human ATP8B1 (ATPase phospholipid transporting 8B1).
Genome Resources: Alliance (1),  Gene:100148342 (1),  Ensembl(GRCz11):ENSDARG00000060980 (2)
GENE EXPRESSION No data available
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa6661 Point Mutation Unknown Premature Stop ENU
sa9801 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14588 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23844 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23845 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa23846 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37209 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37210 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa37211 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43566 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH atp8b1 HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    benign recurrent intrahepatic cholestasis 1 Alliance Cholestasis, benign recurrent intrahepatic 243300
    intrahepatic cholestasis of pregnancy 1 Alliance Cholestasis, intrahepatic, of pregnancy, 1 147480
    progressive familial intrahepatic cholestasis 1 Alliance Cholestasis, progressive familial intrahepatic 1 211600
    DISEASE ASSOCIATED WITH atp8b1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process phospholipid transport (more)
    Cellular Component integral component of membrane (more)
    Molecular Function ATPase-coupled intramembrane lipid transporter activity (more)
    GO Terms (all 11)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR001757 P-type ATPase
    Family IPR006539 P-type ATPase, subfamily IV
    Homologous_superfamily IPR008250 P-type ATPase, A domain superfamily
    PTM IPR018303 P-type ATPase, phosphorylation site
    Homologous_superfamily IPR023214 HAD superfamily
    Homologous_superfamily IPR023298 P-type ATPase, transmembrane domain superfamily
    Homologous_superfamily IPR023299 P-type ATPase, cytoplasmic domain N
    Family IPR030346 Phospholipid-transporting ATPase IC
    Domain IPR032630 P-type ATPase, C-terminal
    Domain IPR032631 P-type ATPase, N-terminal
    Homologous_superfamily IPR036412 HAD-like superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA atp8b1-202 (1)    Ensembl 4543
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM atp8b1 No data available
    MARKER RELATIONSHIPS
    atp8b1 Contained in: [BAC] CH73-161L13 (1), CH211-167H3 (1), CH211-180B7 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_001920475 (1) 4601 bp
    Genomic GenBank:CT033824 (1) 141377 bp
    Select Tool
    Polypeptide UniProtKB:E7FFK0 (1) 1249 aa
    Sequence Information (all 9)
    ORTHOLOGY for atp8b1 ( Chr: 21 )
    CITATIONS (15)