ZFIN ID: ZDB-GENE-091113-9
Gene Name: ADAM metallopeptidase with thrombospondin type 1 motif, 6
Gene Symbol: adamts6    Nomenclature History

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Previous Name: si:dkeyp-7g10.1

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 10 Mapping Details/Browsers
Description: Predicted to have metalloendopeptidase activity. Predicted to be involved in proteolysis. Is expressed in several structures, including digestive system; eye; heart; pleuroperitoneal region; and thymus. Orthologous to human ADAMTS6 (ADAM metallopeptidase with thrombospondin type 1 motif 6).
Genome Resources: Alliance (1),  Gene:569099 (1),  Ensembl(GRCz11):ENSDARG00000041982 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa13308 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa14859 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • PHENOTYPE No data available
    DISEASE ASSOCIATED WITH adamts6 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH adamts6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process proteolysis (more)
    Molecular Function metalloendopeptidase activity (more)
    GO Terms (all 4)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Repeat IPR000884 Thrombospondin type-1 (TSP1) repeat
    Domain IPR001590 Peptidase M12B, ADAM/reprolysin
    Domain IPR002870 Peptidase M12B, propeptide
    Domain IPR010294 ADAM-TS Spacer 1
    Domain IPR010909 PLAC
    Family IPR013273 ADAMTS/ADAMTS-like
    Homologous_superfamily IPR024079 Metallopeptidase, catalytic domain superfamily
    Homologous_superfamily IPR036383 Thrombospondin type-1 (TSP1) repeat superfamily
    Domain IPR041645 ADAM cysteine-rich domain 2
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA adamts6-201 (1)    Ensembl 3351
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM adamts6 No data available
    MARKER RELATIONSHIPS
    adamts6 Contained in: [BAC] DKEY-121H11 (1) (order this), DKEYP-7G10 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_009305175 (1)
    Genomic GenBank:CR450775 (1) 132227 bp
    Select Tool
    Polypeptide UniProtKB:E7FCQ4 (1) 1116 aa
    Sequence Information (all 21)
    ORTHOLOGY for adamts6 ( Chr: 10 )
    CITATIONS (12)