Gene

yme1l1a

ID

ZDB-GENE-091113-41

Name

YME1-like 1a

Symbol

yme1l1a Nomenclature History

Previous Names

si:dkey-229j15.3

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have ATP-dependent peptidase activity. Predicted to be involved in mitochondrion organization and protein quality control for misfolded or incompletely synthesized proteins. Predicted to localize to mitochondrial inner membrane. Human ortholog(s) of this gene implicated in optic atrophy 11. Orthologous to human YME1L1 (YME1 like 1 ATPase).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With yme1l1a Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
optic atrophy 11	Alliance	?Optic atrophy 11	617302

Associated With yme1l1a Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR003960	ATPase, AAA-type, conserved site
Domain	IPR000642	Peptidase M41
Domain	IPR003593	AAA+ ATPase domain
Domain	IPR003959	ATPase, AAA-type, core
Domain	IPR041569	AAA ATPase, AAA+ lid domain
Family	IPR005936	ATP-dependent zinc metalloprotease, FtsH
Homologous_superfamily	IPR027417	P-loop containing nucleoside triphosphate hydrolase
Homologous_superfamily	IPR037219	Peptidase M41-like

Domain Details Per Protein

Protein	Length	AAA ATPase, AAA+ lid domain	AAA+ ATPase domain	ATPase, AAA-type, conserved site	ATPase, AAA-type, core	ATP-dependent zinc metalloprotease, FtsH	Peptidase M41	Peptidase M41-like	P-loop containing nucleoside triphosphate hydrolase
UniProtKB:E7EZJ5 InterPro	729
UniProtKB:A0A8M1RL79 InterPro	721

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	yme1l1a-202 (1) Ensembl	Havana	3017 nt	Select Tool ZFIN BLAST NCBI BLAST Ensembl UCSC BLAT

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations