Gene

prex2

ID

ZDB-GENE-091113-37

Name

phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 2

Symbol

prex2 Nomenclature History

Previous Names

si:ch211-278g15.1

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have Rac guanyl-nucleotide exchange factor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to localize to plasma membrane. Orthologous to human PREX2 (phosphatidylinositol-3,4,5-trisphosphate dependent Rac exchange factor 2).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

No data available

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With prex2 Human Ortholog

No data available

Associated With prex2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR001331	Guanine-nucleotide dissociation stimulator, CDC24, conserved site
Domain	IPR000219	Dbl homology (DH) domain
Domain	IPR000591	DEP domain
Domain	IPR001478	PDZ domain
Domain	IPR001849	Pleckstrin homology domain
Family	IPR051832	Regulators of mTOR signaling and Rac activation
Homologous_superfamily	IPR011993	PH-like domain superfamily
Homologous_superfamily	IPR035899	Dbl homology (DH) domain superfamily
Homologous_superfamily	IPR036034	PDZ superfamily
Homologous_superfamily	IPR036388	Winged helix-like DNA-binding domain superfamily
Homologous_superfamily	IPR036390	Winged helix DNA-binding domain superfamily

Domain Details Per Protein

Protein	Length	Dbl homology (DH) domain	Dbl homology (DH) domain superfamily	DEP domain	Guanine-nucleotide dissociation stimulator, CDC24, conserved site	PDZ domain	PDZ superfamily	PH-like domain superfamily	Pleckstrin homology domain	Regulators of mTOR signaling and Rac activation	Winged helix DNA-binding domain superfamily	Winged helix-like DNA-binding domain superfamily
UniProtKB:E7F2H9 InterPro	1600

Transcripts

Genome Browsers

NCBI

Ensembl

ZFIN

Type	Name	Annotation Method	Has Havana Data	Length (nt)	Analysis
mRNA	prex2-201 (1) Ensembl	Ensembl		6,069 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations