Community Action Needed: Please respond to the NIH RFI
Gene

ppp3ca

ID
ZDB-GENE-091113-24
Name
protein phosphatase 3, catalytic subunit, alpha isozyme
Symbol
ppp3ca Nomenclature History
Previous Names
  • fj46e08
  • si:dkeyp-79c2.2
  • wu:fj46e08
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to enable calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Predicted to be involved in calcineurin-NFAT signaling cascade. Predicted to be part of calcineurin complex. Predicted to be active in cytosol. Is expressed in brain; heart; integument; and olfactory epithelium. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 91. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
2 figures from Hammond et al., 2010
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ppp3ca Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
developmental and epileptic encephalopathy 91 Alliance Developmental and epileptic encephalopathy 91 617711
Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development 618265
Associated With ppp3ca Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR004843 Calcineurin-like phosphoesterase domain, ApaH type
Domain IPR006186 Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
Domain IPR041751 PP2B, metallophosphatase domain
Family IPR043360 PP2B
Homologous_superfamily IPR029052 Metallo-dependent phosphatase-like
Domain Details Per Protein
Protein Length Calcineurin-like phosphoesterase domain, ApaH type Metallo-dependent phosphatase-like PP2B PP2B, metallophosphatase domain Serine/threonine-specific protein phosphatase/bis(5-nucleosyl)-tetraphosphatase
UniProtKB:F1QD93 521
UniProtKB:E9QD09 505
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations