ZFIN ID: ZDB-GENE-091113-24
Gene Name: protein phosphatase 3, catalytic subunit, alpha isozyme
Gene Symbol: ppp3ca    Nomenclature History

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Previous Names: fj46e08, si:dkeyp-79c2.2, wu:fj46e08

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 21 Mapping Details/Browsers
Description: Predicted to have calmodulin binding activity and calmodulin-dependent protein phosphatase activity. Predicted to be involved in calcineurin-NFAT signaling cascade. Predicted to localize to calcineurin complex and cytosol. Is expressed in brain; heart; integument; and olfactory epithelium. Human ortholog(s) of this gene implicated in infantile or early childhood epileptic encephalopathy 1. Orthologous to human PPP3CA (protein phosphatase 3 catalytic subunit alpha).
Genome Resources: Alliance (1),  Gene:794574 (1),  Ensembl(GRCz11):ENSDARG00000004988 (2)
PHENOTYPE No data available
DISEASE ASSOCIATED WITH ppp3ca HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
infantile or early childhood epileptic encephalopathy 1 Alliance Epileptic encephalopathy, infantile or early childhood, 1 617711
Arthrogryposis, cleft palate, craniosynostosis, and impaired intellectual development 618265
DISEASE ASSOCIATED WITH ppp3ca VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process calcineurin-mediated signaling (more)
Cellular Component calcineurin complex (more)
Molecular Function hydrolase activity (more)
GO Terms (all 9)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA ppp3ca-202 (1)    Ensembl 2063
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM ppp3ca No data available
MARKER RELATIONSHIPS
ppp3ca Contained in: [BAC] DKEY-222K23 (1) (order this), DKEYP-79C2 (1)
ppp3ca Encodes: [EST] fj46e08
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001198550 (1) 3513 nt
Genomic GenBank:CR759846 (1) 163118 nt
Select Tool
Polypeptide UniProtKB:F1QD93 (1) 521 aa
Sequence Information (all 12)
ORTHOLOGY for ppp3ca ( Chr: 21 )
CITATIONS (23)