Gene

ubr1

ID
ZDB-GENE-091110-2
Name
ubiquitin protein ligase E3 component n-recognin 1
Symbol
ubr1 Nomenclature History
Previous Names
None
Type
protein_coding_gene
Location
Chr: 17 Mapping Details/Browsers
Description
Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in protein ubiquitination and ubiquitin-dependent protein catabolic process via the N-end rule pathway. Predicted to act upstream of or within protein catabolic process. Predicted to be part of ubiquitin ligase complex. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Johanson-Blizzard syndrome. Orthologous to human UBR1 (ubiquitin protein ligase E3 component n-recognin 1).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
No data available
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
No data available
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With ubr1 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Johanson-Blizzard syndrome Alliance Johanson-Blizzard syndrome 243800
Associated With ubr1 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR003126 Zinc finger, UBR-type
Domain IPR003769 Adaptor protein ClpS, core
Family IPR039164 E3 ubiquitin-protein ligase UBR1-like
Homologous_superfamily IPR014719 Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like
Homologous_superfamily IPR036390 Winged helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Adaptor protein ClpS, core E3 ubiquitin-protein ligase UBR1-like Ribosomal protein L7/L12, C-terminal/adaptor protein ClpS-like Winged helix DNA-binding domain superfamily Zinc finger, UBR-type
UniProtKB:F8W4R2 414
UniProtKB:A2RV49 871
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Gene Tree
Ensembl
Citations