ZFIN ID: ZDB-GENE-091027-1
Gene Name: transforming growth factor, beta receptor 1 b
Gene Symbol: tgfbr1b    Nomenclature History

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Previous Name: alk5b (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have SMAD binding activity; activin binding activity; and transmembrane receptor protein serine/threonine kinase activity. Predicted to be involved in several processes, including heart development; protein phosphorylation; and transmembrane receptor protein serine/threonine kinase signaling pathway. Predicted to localize to activin receptor complex. Is expressed in endoderm; heart; nervous system; pharyngeal arch; and somite. Human ortholog(s) of this gene implicated in Ferguson-Smith tumor; Loeys-Dietz syndrome 1; Lynch syndrome; and urinary bladder cancer. Orthologous to human TGFBR1 (transforming growth factor beta receptor 1).
Genome Resources: Alliance (1),  Gene:792928 (1),  Ensembl(GRCz11):ENSDARG00000042259 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH tgfbr1b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Loeys-Dietz syndrome 1 Alliance Loeys-Dietz syndrome 1 609192
{Multiple self-healing squamous epithelioma, susceptibility to} 132800
DISEASE ASSOCIATED WITH tgfbr1b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process phosphorylation (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 25)
PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA tgfbr1b-201 (1)    Ensembl 1918
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM tgfbr1b No data available
MARKER RELATIONSHIPS
tgfbr1b Contained in: [Fosmid] CH1073-59L16 (1), CH1073-209H20 (1), CH1073-293G9 (1)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:NM_001115059 (1) 1917 nt
Genomic GenBank:FP016176 (1) 38091 nt
Select Tool
Polypeptide UniProtKB:B0EXP7 (1) 505 aa
Sequence Information (all 12)
ORTHOLOGY for tgfbr1b ( Chr: 24 )
CITATIONS (29)