ZFIN ID: ZDB-GENE-091027-1
Gene Name: transforming growth factor, beta receptor 1 b
Gene Symbol: tgfbr1b    Nomenclature History

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Previous Name: alk5b (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Predicted to have several functions, including SMAD binding activity; activin binding activity; and transforming growth factor beta receptor activity, type I. Predicted to be involved in activin receptor signaling pathway; pattern specification process; and transforming growth factor beta receptor signaling pathway. Predicted to localize to the activin receptor complex. Human ortholog(s) of this gene implicated in Ferguson-Smith tumor; Loeys-Dietz syndrome 1; Lynch syndrome; and urinary bladder cancer. Is expressed in endoderm; heart; nervous system; pharyngeal arch; and somite. Orthologous to human TGFBR1 (transforming growth factor beta receptor 1).
Genome Resources: Alliance (1),  Gene:792928 (1),  Ensembl(GRCz11):ENSDARG00000042259 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS No data available
PHENOTYPE No data available
DISEASE ASSOCIATED WITH tgfbr1b HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Loeys-Dietz syndrome 1 Alliance Loeys-Dietz syndrome 1 609192
{Multiple self-healing squamous epithelioma, susceptibility to} 132800
DISEASE ASSOCIATED WITH tgfbr1b VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process phosphorylation (more)
Cellular Component integral component of membrane (more)
Molecular Function ATP binding (more)
GO Terms (all 25)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Family IPR000333 Ser/Thr protein kinase, TGFB receptor
Domain IPR000472 Activin types I and II receptor domain
Domain IPR000719 Protein kinase domain
Domain IPR003605 GS domain
Active_site IPR008271 Serine/threonine-protein kinase, active site
Homologous_superfamily IPR011009 Protein kinase-like domain superfamily
Binding_site IPR017441 Protein kinase, ATP binding site
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA tgfbr1b-201 (1)    Ensembl 1918
Browsers: UCSCNCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM tgfbr1b No data available
MARKER RELATIONSHIPS
tgfbr1b Contained in: [Fosmid] CH1073-59L16 (1), CH1073-209H20 (1), CH1073-293G9 (1)
SEQUENCE INFORMATION
Type Accession # Length (bp/aa) Analysis
RNA RefSeq:NM_001115059 (1) 1917 bp
Genomic GenBank:FP016176 (1) 38091 bp
Select Tool
Polypeptide UniProtKB:B0EXP7 (1) 505 aa
Sequence Information (all 12)
ORTHOLOGY for tgfbr1b ( Chr: 24 )
CITATIONS (29)