Gene

slc22a5

ID
ZDB-GENE-091012-1
Name
solute carrier family 22 member 5
Symbol
slc22a5 Nomenclature History
Previous Names
  • octn2 (1)
  • si:ch211-25g7.3
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Exhibits carnitine transmembrane transporter activity. Involved in carnitine transport and heme biosynthetic process. Predicted to localize to integral component of membrane. Is expressed in several structures, including gill; head; liver; pleuroperitoneal region; and skeletal muscle. Human ortholog(s) of this gene implicated in Crohn's disease; cardiomyopathy; inherited metabolic disorder; rheumatoid arthritis; and systemic primary carnitine deficiency disease. Orthologous to several human genes including SLC22A5 (solute carrier family 22 member 5).
Genome Resources
Note
None
Expression
All Expression Data
2 figures from 2 publications
Cross-Species Comparison
High Throughput Data
No data available
Thisse Expression Data
Wild Type Expression Summary
Phenotype
All Phenotype Data
1 Figure from Nilsson et al., 2009
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With slc22a5 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
systemic primary carnitine deficiency disease Alliance Carnitine deficiency, systemic primary 212140
Associated With slc22a5 Via Experimental Models
No data available
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Conserved_site IPR005829 Sugar transporter, conserved site
Domain IPR020846 Major facilitator superfamily domain
Family IPR005828 Major facilitator, sugar transporter-like
Homologous_superfamily IPR036259 MFS transporter superfamily
Domain Details Per Protein
Protein Length Major facilitator, sugar transporter-like Major facilitator superfamily domain MFS transporter superfamily Sugar transporter, conserved site
UniProtKB:A0A0R4IMT8 549
Transcripts
Genome Browsers
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Gene Tree
Ensembl
Citations