ZFIN ID: ZDB-GENE-091005-1
Gene Name: lysine (K)-specific demethylase 6B, a
Gene Symbol: kdm6ba    Nomenclature History

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Previous Name: jmjd3b (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 7 Mapping Details/Browsers
Description: Predicted to have histone demethylase activity (H3-K27 specific) and metal ion binding activity. Involved in heart development and heart trabecula morphogenesis. Predicted to localize to nucleus. Is expressed in brain; heart; and otic vesicle. Orthologous to human KDM6B (lysine demethylase 6B).
Genome Resources: Alliance (1),  Gene:556678 (1),  Ensembl(GRCz11):ENSDARG00000088087 (2)
GENE EXPRESSION
All Expression Data: 4 figures from 2 publications
Wild-type Stages, Structures: Cleavage:4-cell (1.0h-1.25h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
 
High Throughput Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
b1308 Small Deletion Exon 14 Frameshift, Premature Stop CRISPR
sa8805 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa16587 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa18869 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa26939 Point Mutation Unknown Premature Stop ENU
    sa40872 Point Mutation Unknown Splice Site ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-kdm6ba 1
    MO1-kdm6ba N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH kdm6ba HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    Neurodevelopmental disorder with coarse facies and mild distal skeletal abnormalities 618505
    DISEASE ASSOCIATED WITH kdm6ba VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process heart development (more)
    Cellular Component nucleus (more)
    Molecular Function histone demethylase activity (H3-K27 specific) (more)
    GO Terms (all 12)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA kdm6ba-203 (1)    Ensembl 8578
    ncRNA kdm6ba-002 (1) 855
    kdm6ba-003 (1) 706
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM kdm6ba No data available
    MARKER RELATIONSHIPS
    kdm6ba Contained in: [BAC] CH211-262E4 (1), CH211-265E16 (1), DKEY-46E6 (order this), DKEY-85K7 (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_005172240 (1) 8707 nt
    Genomic GenBank:BX005336 (1) 233826 nt Blast at MegaBLAST
    Polypeptide UniProtKB:A0A1D5NSI1 (1) 1996 aa
    Sequence Information (all 20)
    ORTHOLOGY for kdm6ba ( Chr: 7 )
    CITATIONS (22)