ZFIN ID: ZDB-GENE-090930-2
Gene Name: unc-119 homolog a (C. elegans)
Gene Symbol: unc119a    Nomenclature History

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Previous Names: unc-119 (1), Unc119 (1), rtg4, si:dkey-234f12.7, zfUnc119homA (1)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 15 Mapping Details/Browsers
Description: Predicted to have lipid binding activity. Predicted to be involved in several processes, including lipoprotein transport; negative regulation of endocytosis; and positive regulation of protein tyrosine kinase activity. Predicted to localize to the intercellular bridge and microtubule cytoskeleton. Human ortholog(s) of this gene implicated in idiopathic CD4-positive T-lymphocytopenia. Is expressed in blood cell and vascular endothelium. Orthologous to human UNC119 (unc-119 lipid binding chaperone).
Genome Resources: Alliance (1),  Gene:566824 (1),  Ensembl(GRCz11):ENSDARG00000034453 (2)
GENE EXPRESSION
All Expression Data: Fig. 2 from Cannon et al., 2013
Wild-type Stages, Structures: Pharyngula:Prim-5 (24.0h-30.0h) to Pharyngula:Prim-5 (24.0h-30.0h)
 
Curated Microarray Expression: GEO (1) , Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Sequence Targeting Reagents
Targeting Reagent Created Alleles Publications
MO1-unc119a N/A 1
PHENOTYPE No data available
DISEASE ASSOCIATED WITH unc119a HUMAN ORTHOLOG
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
?Cone-rod dystrophy
?Immunodeficiency 13 615518
DISEASE ASSOCIATED WITH unc119a VIA EXPERIMENTAL MODELS No data available
GENE ONTOLOGY
Ontology GO Term
Biological Process nervous system development (more)
Cellular Component centrosome (more)
Molecular Function lipid binding (more)
GO Terms (all 12)
PROTEIN FAMILIES, DOMAINS AND SITES
Type InterPro ID Name
Domain IPR008015 GMP phosphodiesterase, delta subunit
Family IPR032977 Protein unc-119 homologue A-like
Homologous_superfamily IPR014756 Immunoglobulin E-set
Homologous_superfamily IPR037036 GMP phosphodiesterase, delta subunit superfamily
TRANSCRIPTS
Type Name Length (nt) Analysis
mRNA unc119a-201 (1)    Ensembl 1219
Browsers: NCBIEnsemblZFIN
INTERACTIONS AND PATHWAYS
ANTIBODIES No data available
PLASMIDS No data available
CONSTRUCTS WITH SEQUENCES FROM unc119a No data available
MARKER RELATIONSHIPS
unc119a Contained in: [BAC] DKEY-234F12 (order this)
SEQUENCE INFORMATION
Type Accession # Length (nt/aa) Analysis
RNA RefSeq:XM_690112 (1)
Genomic GenBank:BX663513 (1) 249413 nt Blast at MegaBLAST
Polypeptide UniProtKB:F1QE32 (1) 204 aa
Sequence Information (all 13)
ORTHOLOGY for unc119a ( Chr: 15 )
CITATIONS (17)