ZFIN ID: ZDB-GENE-090918-1
Gene Name: neuroligin 1
Gene Symbol: nlgn1    Nomenclature History

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 11 Mapping Details/Browsers
Description: Predicted to have neurexin family protein binding activity and signaling receptor activity. Involved in sprouting angiogenesis. Predicted to localize to the cell surface; integral component of plasma membrane; and synapse. Is expressed in several structures, including brain; cardiovascular system; eye; gonad; and swim bladder. Orthologous to human NLGN1 (neuroligin 1).
Genome Resources: Alliance (1),  Gene:100002610 (1),  Ensembl(GRCz11):ENSDARG00000077710 (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
fh309 Point Mutation Unknown Unknown ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • fh310 Point Mutation Unknown Unknown ENU
    nlgn1_unrecovered Point Mutation Unknown Unknown ENU
    sa35027 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    CRISPR1-nlgn1
    2
    MO1-nlgn1 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH nlgn1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH nlgn1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process sprouting angiogenesis (more)
    Cellular Component excitatory synapse (more)
    Molecular Function neurexin family protein binding (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR000460 Neuroligin
    Domain IPR002018 Carboxylesterase, type B
    Conserved_site IPR019819 Carboxylesterase type B, conserved site
    Homologous_superfamily IPR029058 Alpha/Beta hydrolase fold
    Family IPR030022 Neuroligin-1
    Family IPR030025 Neuroligin 4
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA nlgn1-202 (1)    Ensembl 2203
    nlgn1-203 (1)    Ensembl 153
    Browsers: UCSCNCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM nlgn1 No data available
    MARKER RELATIONSHIPS
    nlgn1 Contained in: [BAC] CH211-28A12 (1), CH211-119C22 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001142265 (1) 2544 bp
    Genomic GenBank:BX005472 (1) 158170 bp
    Select Tool
    Polypeptide UniProtKB:D2X2F9 (1) 867 aa
    Sequence Information (all 32)
    ORTHOLOGY for nlgn1 ( Chr: 11 )
    CITATIONS (29)