ZFIN ID: ZDB-GENE-090915-1
Gene Name: solute carrier family 2 member 1b
Gene Symbol: slc2a1b    Nomenclature History

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Previous Names: si:dkey-92f12.1, zglut1a (2)

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 6 Mapping Details/Browsers
Description: Exhibits D-glucose transmembrane transporter activity. Involved in sprouting angiogenesis. Predicted to localize to the integral component of membrane. Human ortholog(s) of this gene implicated in brain disease (multiple); carbohydrate metabolic disorder; myelomeningocele; obesity; and type 2 diabetes mellitus. Is expressed in several structures, including heart; intestine; kidney; liver; and yolk. Orthologous to human SLC2A1 (solute carrier family 2 member 1).
Genome Resources: Alliance (1),  Gene:100321338 (1),  Ensembl(GRCz11):ENSDARG00000007412 (2)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la025620Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa1752 Point Mutation Unknown Premature Stop ENU
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa7048 Point Mutation Unknown Premature Stop ENU
    sa20811 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-slc2a1b N/A 1
    MO2-slc2a1b N/A 1
    MO3-slc2a1b N/A 1
    DISEASE ASSOCIATED WITH slc2a1b HUMAN ORTHOLOG
    Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
    childhood onset GLUT1 deficiency syndrome 2 Alliance GLUT1 deficiency syndrome 2, childhood onset 612126
    dystonia 9 Alliance Dystonia 9 601042
    idiopathic generalized epilepsy 12 Alliance {Epilepsy, idiopathic generalized, susceptibility to, 12} 614847
    GLUT1 deficiency syndrome 1, infantile onset, severe 606777
    Stomatin-deficient cryohydrocytosis with neurologic defects 608885
    DISEASE ASSOCIATED WITH slc2a1b VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process sprouting angiogenesis (more)
    Cellular Component integral component of membrane (more)
    Molecular Function D-glucose transmembrane transporter activity (more)
    GO Terms (all 6)
    PROTEIN FAMILIES, DOMAINS AND SITES
    Type InterPro ID Name
    Family IPR003663 Sugar/inositol transporter
    Family IPR005828 Major facilitator, sugar transporter-like
    Conserved_site IPR005829 Sugar transporter, conserved site
    Domain IPR020846 Major facilitator superfamily domain
    Homologous_superfamily IPR036259 MFS transporter superfamily
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA slc2a1b-201 (1)    Ensembl 1823
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM slc2a1b No data available
    MARKER RELATIONSHIPS
    slc2a1b Contained in: [BAC] CH73-85E16 (1), DKEY-92F12 (1) (order this)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_002662528 (1) 2434 bp
    Genomic GenBank:CR788236 (1) 180503 bp
    Select Tool
    Polypeptide UniProtKB:F1R0Q1 (1) 489 aa
    Sequence Information (all 10)
    ORTHOLOGY for slc2a1b ( Chr: 6 )
    CITATIONS (32)