Gene
tdp1
- ID
- ZDB-GENE-090909-1
- Name
- tyrosyl-DNA phosphodiesterase 1
- Symbol
- tdp1 Nomenclature History
- Previous Names
- None
- Type
- protein_coding_gene
- Location
- Chr: 17 Mapping Details/Browsers
- Description
- Predicted to have 3'-tyrosyl-DNA phosphodiesterase activity; double-stranded DNA binding activity; and single-stranded DNA binding activity. Predicted to be involved in double-strand break repair and single strand break repair. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in spinocerebellar ataxia type 1 with axonal neuropathy. Orthologous to human TDP1 (tyrosyl-DNA phosphodiesterase 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 3 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Zaksauskaite et al., 2021
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spinocerebellar ataxia with axonal neuropathy 1 | Alliance | ?Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy 1 | 607250 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Family | IPR010347 | Tyrosyl-DNA phosphodiesterase I |
Domain Details Per Protein
| Protein | Length | Tyrosyl-DNA phosphodiesterase I |
|---|---|---|
|
UniProtKB:F8W5U2
|
615 |
Interactions and Pathways
No data available
Plasmids
No data available