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General Information
ZIRC
ZFIN ID: ZDB-GENE-090821-1
Gene Name: low density lipoprotein receptor-related protein 6
Gene Symbol: lrp6
Sequence Ontology ID : SO:0001217

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(Including Attributions)
Location: Ambiguous Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have Wnt-activated receptor activity and Wnt-protein binding activity. Involved in canonical Wnt signaling pathway and dorsal/ventral axis specification. Predicted to localize to the  ...
GENE EXPRESSION
All Expression Data: 2 figures from 2 publications
Wild-type Stages, Structures: Pharyngula:Prim-25 (36.0h-42.0h) to Hatching:Long-pec (48.0h-60.0h)
 
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
la028070Tg Transgenic Insertion Unknown Unknown DNA
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa43347 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Targeting reagents:
    PHENOTYPE
    Data: 2 figures from 2 publications
    Observed in:
    DISEASE ASSOCIATED WITH lrp6 HUMAN ORTHOLOG
    Disease Ontology Term OMIM Term OMIM Phenotype ID
    coronary artery disease {Coronary artery disease, autosomal dominant, 2} 610947
    Tooth agenesis, selective, 7 616724
    DISEASE ASSOCIATED WITH lrp6 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process canonical Wnt signaling pathway (more)
    Cellular Component integral component of membrane (more)
    Molecular Function Wnt-activated receptor activity (more)
    GO Terms (all 10)
    TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA lrp6-001 (1) 4172
    lrp6-002 (1) 985
     Withdrawn Transcriptsextinct
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYS
    SignaFish
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM lrp6 No data available
    MARKER RELATIONSHIPS
    lrp6 Contained in: [Fosmid] CH1073-159I21 (1) (order this), CH1073-404B14 (1) (order this), ZFOS-932H1 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_001134684 (1) 4863 bp
    Genomic RefSeq:NW_003336643 (1) Blast at MegaBLAST
    Polypeptide UniProtKB:B5L5I6 (1) 1620 aa
    Sequence Clusters UniGene:88486 (1)
    Sequence Information (all 15)
    ORTHOLOGY for lrp6 ( Ambiguous )
    CITATIONS (29)