ZFIN ID: ZDB-GENE-090814-1
Gene Name: transcription factor 4
Gene Symbol: tcf4
Previous Name: tcf4l
Location: Chr: 21 Mapping Details/Browsers
Nomenclature History
GENE EXPRESSION
All Expression Data: 8 figures from 6 publications
Wild-type Stages, Structures: Segmentation:10-13 somites (14.0h-16.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  caudal tuberculum, cerebellum, dorsal telencephalon, hindbrain (all 17) expand
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Targeting reagents: MO1-tcf4 (1), MO2-tcf4 (1), MO3-tcf4 (1)
PHENOTYPE
Data: Fig. 4 from Brockschmidt et al., 2011
Observed in: embryo development, fourth ventricle, post-vent region
DISEASE ASSOCIATED WITH tcf4 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
Fuchs' endothelial dystrophy Corneal dystrophy, Fuchs endothelial, 3 613267
Pitt-Hopkins syndrome Pitt-Hopkins syndrome 610954
GENE ONTOLOGY
Ontology GO Term
Biological Process brain development (more)
Cellular Component nucleus (more)
Molecular Function protein dimerization activity (more)
GO Terms (all 12)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR011598 (1)
  • PROSITE:PS50888 (1)
  • Pfam:PF00010 (1)
  • TRANSCRIPTS No data available
    GENE PRODUCT DESCRIPTION
    INTERACTIONS AND PATHWAYSNo data available
    ANTIBODIESNo data available
    PLASMIDSNo data available
    CONSTRUCTS WITH SEQUENCES FROM tcf4 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPSNo data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_017352987 (1) 3099bp
    Genomic GenBank:CABZ01086137 (1) 26067bp
    Select Tool
    Polypeptide UniProtKB:E2J8V4 (1) 677aa
    Sequence Clusters UniGene:153729 (1)
    Sequence Information (all 46)
    OTHER tcf4 GENE PAGES
  • Gene:100526651 (1)
  • ORTHOLOGY for tcf4 (Chr: 21)
    Species Symbol Chromosome Accession # Evidence
    Human TCF4 18
  • Gene:6925
  • OMIM:602272
  • HGNC:11634
  • Amino acid sequence comparison (1)
    Conserved genome location (synteny) (1)
    Mouse Tcf4 18
  • MGI:98506
  • Gene:21413
  • Amino acid sequence comparison (1)
    Download Curated Orthology
    CITATIONS (15)