Gene

tcf4

ID
ZDB-GENE-090814-1
Name
transcription factor 4
Symbol
tcf4 Nomenclature History
Previous Names
  • tcf4l
Type
protein_coding_gene
Location
Chr: 21 Mapping Details/Browsers
Description
Predicted to enable protein dimerization activity. Acts upstream of or within brain development and lens development in camera-type eye. Is expressed in several structures, including brain; digestive system; notochord; pectoral fin bud; and retina. Used to study Pitt-Hopkins syndrome. Human ortholog(s) of this gene implicated in Fuchs' endothelial dystrophy and Pitt-Hopkins syndrome. Orthologous to human TCF4 (transcription factor 4).
Genome Resources
Note
None
Comparative Information
Expression
All Expression Data
9 figures from 7 publications
Cross-Species Comparison
High Throughput Data
Thisse Expression Data
No data available
Wild Type Expression Summary
Phenotype
All Phenotype Data
4 figures from 3 publications
Cross-Species Comparison
Alliance
Phenotype Summary
Mutations
Mutants
Sequence Targeting Reagents
Human Disease
Associated With tcf4 Human Ortholog
Disease Ontology Term Multi-Species Data OMIM Term OMIM Phenotype ID
Fuchs' endothelial dystrophy Alliance Corneal dystrophy, Fuchs endothelial, 3 613267
Pitt-Hopkins syndrome Alliance Pitt-Hopkins syndrome 610954
Associated With tcf4 Via Experimental Models
Gene Ontology
Protein Domains
Domain, Family, and Site Summary
Type InterPro ID Name
Domain IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain
Homologous_superfamily IPR036638 Helix-loop-helix DNA-binding domain superfamily
Domain Details Per Protein
Protein Length Helix-loop-helix DNA-binding domain superfamily Myc-type, basic helix-loop-helix (bHLH) domain
UniProtKB:E2J8V4 677
Transcripts
Genome Browsers
No data available
Interactions and Pathways
No data available
Antibodies
No data available
Plasmids
No data available
Constructs
Marker Relationships
Sequences
Orthology
Comparative Orthology
Alliance
Citations