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General Information
ZIRC
ZFIN ID: ZDB-GENE-090814-1
Gene Name: transcription factor 4
Gene Symbol: tcf4
Sequence Ontology ID : SO:0001217

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Previous Name: tcf4l

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(Including Attributions)
Location: Chr: 21 Mapping Details/Browsers
Nomenclature History
AUTOMATED DESCRIPTION
Predicted to have protein dimerization activity. Involved in brain development and lens development in camera-type eye. Used to study Pitt-Hopkins syndrome. Human ortholog(s) of this gene implicated  ...
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
wi702 Small Deletion Unknown Unknown CRISPR
Targeting reagents:
DISEASE ASSOCIATED WITH tcf4 HUMAN ORTHOLOG
Disease Ontology Term OMIM Term OMIM Phenotype ID
Fuchs' endothelial dystrophy Corneal dystrophy, Fuchs endothelial, 3 613267
Pitt-Hopkins syndrome Pitt-Hopkins syndrome 610954
DISEASE ASSOCIATED WITH tcf4 VIA EXPERIMENTAL MODELS
Human Disease Fish Conditions Citations
Pitt-Hopkins syndrome AB/TU + MO1-tcf4 + MO2-tcf4 standard conditions Brockschmidt et al., 2011
GENE ONTOLOGY
Ontology GO Term
Biological Process brain development (more)
Molecular Function protein dimerization activity (more)
GO Terms (all 3)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR011598 (1)
  • InterPro:IPR036638 (1)
  • PROSITE:PS50888 (1)
  • Pfam:PF00010 (1)
  • TRANSCRIPTS No data available
    GENE PRODUCT DESCRIPTION No description available
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tcf4 No data available
    MARKER RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_021468942 (1)
    Genomic GenBank:CABZ01086137 (1) 26067 bp
    Select Tool
    Polypeptide UniProtKB:E2J8V4 (1) 677 aa
    Sequence Clusters UniGene:153729 (1)
    Sequence Information (all 47)
    OTHER tcf4 GENE PAGES
  • Alliance (1)
  • Gene:100526651 (1)
  • ORTHOLOGY for tcf4 ( Chr: 21 )
    CITATIONS (18)