Research
General Information
ZIRC
ZFIN ID: ZDB-GENE-090814-1
Gene Name: transcription factor 4
Gene Symbol: tcf4
Previous Name: tcf4l
Location: Chr: 21   Details
Nomenclature History
GENE EXPRESSION
All Expression Data: 8 figures from 6 publications
Wild-type Stages, Structures: Segmentation:10-13 somites (14.0h-16.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  caudal tuberculum, cerebellum, dorsal telencephalon, hindbrain (all 17) expand
MUTANTS AND TARGETED KNOCKDOWNS
Knockdown reagents: MO1-tcf4 (1), MO2-tcf4 (1), MO3-tcf4 (1)
PHENOTYPE
Data: Fig. 4 from Brockschmidt et al., 2011
Observed in: embryo development, fourth ventricle, post-vent region

Phenotype of Human Orthologue OMIM Phenotype ID
Pitt-Hopkins syndrome 610954
GENE ONTOLOGY
Ontology GO Term
Biological Process brain development (more)
Molecular Function protein dimerization activity (more)
GO Terms (all 3)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR011598 (1)
  • PROSITE:PS50888 (1)
  • Pfam:PF00010 (1)
  • TRANSCRIPTS No data available
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM tcf4 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS No data available
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:XM_009301658 (1) 990 bp
    Genomic RefSeq:NW_003335915 (1) 58219 bp Blast at MegaBLAST
    Polypeptide UniProtKB:E2J8V4 (1) 677 aa
    Sequence Clusters UniGene:153729 (1)
    Sequence Information (all 10)
    OTHER tcf4 GENE PAGES
  • Gene:100526651 (1)
  • Ensembl(Zv9):ENSDARG00000087652 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish tcf4 21  
    Human TCF4 18 (18q21.1)
  • OMIM:602272
  • Gene:6925
  • Mouse Tcf4 18 ( 43.23 cM)
  • MGI:98506
  • Gene:21413
  • Orthology Details
    CITATIONS (14)