Gene

tbx22

ID

ZDB-GENE-090626-2

Name

T-box transcription factor 22

Symbol

tbx22 Nomenclature History

Previous Names

None

Type

protein_coding_gene

Location

Chr: 14 Mapping Details/Browsers

Description

Predicted to have DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II activating transcription factor binding activity; and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to be involved in cell fate specification; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Predicted to localize to nucleus. Is expressed in mandibular arch skeleton; maxilla; paraxial mesoderm; and stomodeum. Human ortholog(s) of this gene implicated in Abruzzo-Erickson syndrome; X-linked cleft palate with or without ankyloglossia; and cleft palate. Orthologous to human TBX22 (T-box transcription factor 22).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

4 figures from 3 publications

Cross-Species Comparison

High Throughput Data

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With tbx22 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Abruzzo-Erickson syndrome	Alliance	?Abruzzo-Erickson syndrome	302905
X-linked cleft palate with or without ankyloglossia	Alliance	Cleft palate with ankyloglossia	303400

Associated With tbx22 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR018186	Transcription factor, T-box, conserved site
Homologous_superfamily	IPR008967	p53-like transcription factor, DNA-binding
Homologous_superfamily	IPR036960	T-box superfamily