ZFIN ID: ZDB-GENE-090612-2
Gene Name: telomeric repeat binding factor (NIMA-interacting) 1
Gene Symbol: terf1    Nomenclature History

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Previous Name: wu:fb74c04

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(Including Attributions)
Gene Type: protein_coding_gene
Location: Chr: 24 Mapping Details/Browsers
Description: Exhibits telomeric DNA binding activity. Predicted to contribute to telomerase activity. Predicted to be involved in negative regulation of cellular metabolic process and telomere maintenance via telomerase. Predicted to localize to nuclear telomere cap complex. Is expressed in several structures, including gill; heart; liver; pleuroperitoneal region; and post-vent region. Orthologous to human TERF1 (telomeric repeat binding factor 1).
Genome Resources: Alliance (1),  Gene:566954 (1),  Ensembl(GRCz11):ENSDARG00000058710 (2)
GENE EXPRESSION
All Expression Data: Fig. 4 from Wagner et al., 2017
Wild-type Stages, Structures: Adult (90d-730d, breeding adult) to Adult (90d-730d, breeding adult)
 
High Throughput Expression: GEO (1) Expression Atlas (1)
MUTATIONS AND SEQUENCE TARGETING REAGENTS
Allele Type Localization Consequence Mutagen Suppliers
sa24459 Point Mutation Unknown Premature Stop ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • sa32480 Point Mutation Unknown Splice Site ENU
  • European Zebrafish Resource Center (EZRC) (order this)
  • Zebrafish International Resource Center (ZIRC) (order this)
  • Sequence Targeting Reagents
    Targeting Reagent Created Alleles Publications
    MO1-terf1 N/A 1
    PHENOTYPE No data available
    DISEASE ASSOCIATED WITH terf1 HUMAN ORTHOLOG No data available
    DISEASE ASSOCIATED WITH terf1 VIA EXPERIMENTAL MODELS No data available
    GENE ONTOLOGY
    Ontology GO Term
    Biological Process telomere maintenance (more)
    Cellular Component nuclear chromosome, telomeric region (more)
    Molecular Function telomeric DNA binding (more)
    GO Terms (all 17)
    PROTEIN FAMILIES, DOMAINS AND SITES No links to external sites available
    TRANSCRIPTS
    Type Name Length (nt) Analysis
    mRNA terf1-201 (1)    Ensembl 1543
    terf1-202 (1)    Ensembl 909
    ncRNA terf1-003 (1)    Ensembl 667
    Browsers: NCBIEnsemblZFIN
    INTERACTIONS AND PATHWAYS
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM terf1 No data available
    MARKER RELATIONSHIPS
    terf1 Contained in: [BAC] CH211-171B20 (1), DKEY-192J17 (1) (order this)
    terf1 Encodes: [EST] fb74c04
    SEQUENCE INFORMATION
    Type Accession # Length (nt/aa) Analysis
    RNA RefSeq:XM_021470295 (1)
    Genomic GenBank:CR318587 (1) 164331 nt
    Select Tool
    Polypeptide UniProtKB:A7MD83 (1) 365 aa
    Sequence Information (all 29)
    ORTHOLOGY for terf1 ( Chr: 24 )
    CITATIONS (20)